Centre for Image Guided Therapy - A Theranostic Approach to Patients with Cancer

图像引导治疗中心 - 癌症患者的治疗诊断方法

• 批准号: MR/M009092/1
• 负责人: Mark Emberton
• 金额: $ 673.64万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM009092%2F1
• 关键词: Centre; Image; Guided; Therapy; Theranostic

Our vision is to revolutionise diagnosis, risk stratification and therapy for people with cancer based on innovations in magnetic resonance (MR) technology. The new system of care will be based on developing a strategy of optimized 'target generation', specific 'target verification' and precise 'target destruction'We use imaging to find out where cancer lies within the body. We call the process of taking an image to find a lesion 'target generation'. Whilst imaging helps to find disease we don't always know whether a lesion on an image is cancer or whether it is benign. Also, if a lesion is cancer we don't often know what that means for the individual patient. By way of explanation, we may know that a particular distribution of cancer spread within the body confers a poorer outcome for a group of patients e.g. a 50% of patients survive after 5-years; however, we often can't tell whether an individual patient will fall into the 50% that survive. Understanding the nature of a lesion detected on imaging and how this impacts on treatment choices and overall treatment outcome is termed 'target verification'.Our proposal seeks to establish a platform to allow new methods and advances we have been making in pre-clinical 'target generation' to be robustly and rapidly developed for clinical use. It also seeks to develop the best imaging technologies and combine these with an understanding of the cellular and molecular environment of cancers in order to significantly improve 'target verification'. The third aspect to our proposal is the development of new technologies to deliver precise treatment to individual cancer sites. We term this 'target destruction'. A range of technologies exist and we aim to provide the environment where the best and most promising of these can be easily translated from conception of idea all the way to clinical application. We have a strong track record in this area with therapies for prostate cancer and we seek to extend this to other cancer sites, initially lung and gastrointestinal cancers. Our proposal brings together a group of scientist with complementary skills in imaging, surgery and engineering in one location through establishing a dedicated Centre for Image Guided Therapy within University College London. Within this we seek to establish a translational imaging facility, which will reflect the type of imaging available within the clinical environment, and will also allow scientists access to the cutting-edge equipment to enable them to develop technological advances rapidly and robustly to a stage that they can be applied for patient benefit.

我们的愿景是基于磁共振（MR）技术的创新，彻底改变癌症患者的诊断、风险分层和治疗。新的护理系统将基于开发一种优化的“目标生成”、特定的“目标验证”和精确的“目标破坏”的策略。我们使用成像来找出癌症在体内的位置。我们称拍摄图像以找到病变的过程为“靶生成”。虽然成像有助于发现疾病，但我们并不总是知道图像上的病变是癌症还是良性的。此外，如果病变是癌症，我们通常不知道这对个体患者意味着什么。通过解释，我们可能知道，癌症在体内扩散的特定分布会给一组患者带来较差的结果，例如，50%的患者在5年后存活;然而，我们通常无法判断单个患者是否会落入50%的存活率。了解成像检测到的病变的性质以及这对治疗选择和整体治疗结果的影响被称为“靶向验证”。我们的建议旨在建立一个平台，使我们在临床前“靶向生成”方面取得的新方法和进展能够稳健快速地发展用于临床。它还寻求开发最好的成像技术，并将这些技术与对癌症细胞和分子环境的理解相结合，以显着提高“目标验证”。我们建议的第三个方面是开发新技术，为个别癌症部位提供精确治疗。我们称之为“目标破坏”。存在一系列技术，我们的目标是提供一个环境，其中最好和最有前途的可以很容易地从概念的想法转化到临床应用。我们在这一领域的前列腺癌治疗方面有着良好的记录，我们寻求将其扩展到其他癌症部位，最初是肺癌和胃肠癌。我们的建议通过在伦敦大学学院内建立一个专门的图像引导治疗中心，将一群在成像，手术和工程方面具有互补技能的科学家聚集在一起。在此范围内，我们寻求建立一个平移成像设施，这将反映临床环境中可用的成像类型，并允许科学家使用尖端设备，使他们能够快速，稳健地发展技术进步，使其能够应用于患者。

项目成果

Replica analysis of overfitting in generalized linear regression models

• DOI: 10.1088/1751-8121/aba028
• 发表时间: 2020-09-11
• 期刊: JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL
• 影响因子: 2.1
• 作者: Coolen, A. C. C.;Sheikh, M.;Antenucci, F.
• 通讯作者: Antenucci, F.

Image-Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System.

• DOI: 10.1002/advs.202105333
• 发表时间: 2022-04
• 期刊: ADVANCED SCIENCE
• 影响因子: 15.1
• 作者: Baker, Rebecca R.;Payne, Christopher;Yu, Yichao;Mohseni, Matin;Connell, John J.;Lin, Fangyu;Harrison, Ian F.;Southern, Paul;Rudrapatna, Umesh S.;Stuckey, Daniel J.;Kalber, Tammy L.;Siow, Bernard;Thorne, Lewis;Punwani, Shonit;Jones, Derek K.;Emberton, Mark;Pankhurst, Quentin A.;Lythgoe, Mark F.
• 通讯作者: Lythgoe, Mark F.

Targeted biopsy of the prostate: does this result in improvement in detection of high-grade cancer or the occurrence of the Will Rogers phenomenon?

• DOI: 10.1111/bju.14806
• 发表时间: 2019-10-01
• 期刊: BJU INTERNATIONAL
• 影响因子: 4.5
• 作者: Bass, Edward J.;Orczyk, Clement;Ahmed, Hashim U.
• 通讯作者: Ahmed, Hashim U.

Editorial Comment.

编辑评论。

• DOI: 10.1097/ju.0000000000001640.01
• 发表时间: 2021
• 期刊: The Journal of urology
• 作者: Bauer,ScottR;Huang,Alison
• 通讯作者: Huang,Alison