Brain Associates of Parent Training on Antisocial Behaviour in Children

有行为问题的儿童在社会和学校环境中反复和持续地具有攻击性，破坏性和破坏规则。了解CP的原因很重要，因为这些儿童更有可能在成年后继续存在问题。这包括酗酒、吸毒、精神疾病、犯罪、家庭暴力、失业和早逝。它们每年也给社会造成数十亿英镑的损失，并给受害者带来巨大的情感代价。脑瘫的根本原因可能很复杂，但有令人信服的证据表明，脑瘫儿童的大脑解剖结构和功能存在差异。然而，没有人分析过是否存在特定的大脑差异：a）预测对变化的抵抗;和/或B）是“可逆的”。为了实现这一目标，我们将使用脑成像技术来分析脑瘫儿童在经过有效验证的父母培训干预前后的大脑，这已被证明可以有效减少脑瘫儿童的反社会行为。如果成功，我们的工作将有助于我们：a）更好地理解大脑CP异常与反社会行为之间的关系，以及B）确定为什么一些CP儿童的反社会行为比其他儿童更难改变。我们的发现也将有助于将未来的研究重点放在CP的分子基础上，并最终导致更好的治疗。

Children with conduct problems (CP) are repetitively and persistently aggressive, destructive and break rules in social and school settings. Understanding the cause(s) of CP is important as these children are much more likely to have continued problems in adult life. This includes alcoholism, drug abuse, mental illness, criminality, domestic violence, unemployment and early death. They also cost society billions of pounds each year and have significant emotional costs on their victims.The underlying cause(s) for CP is probably complex but there is compelling evidence that children with CP have differences in brain anatomy and function. However, no-one has analysed whether there are specific brain differences that: a) predict resistance to change; and/or b) are 'reversible'. To achieve this we will use brain imaging techniques to analyse the brain in CP children before and after a well-validated parent training intervention, which has been demonstrated to effectively reduce antisocial behaviour in CP children.If successful, our work will help us to: a) better understand the relationship between brain abnormalities in CP and antisocial behaviour and b) identify why antisocial behaviour in some children with CP is more resistant to change than others.It is also anticipated that our findings will also assist in focusing future research into the molecular basis of CP, and ultimately lead to better treatments.