Brain Associates of Parent Training on Antisocial Behaviour in Children

有行为问题（CP）的儿童在社会和学校环境中反复和持续地具有攻击性，破坏性和破坏规则。了解CP的原因是很重要的，因为这些孩子在成年后更有可能有持续的问题。这包括酗酒、滥用药物、精神疾病、犯罪、家庭暴力、失业和早逝。它们每年还会给社会造成数十亿英镑的损失，并给受害者带来巨大的情感损失。脑瘫的潜在原因可能很复杂，但有令人信服的证据表明，脑瘫儿童在大脑解剖和功能上存在差异。然而，没有人分析过是否存在特定的大脑差异：a)预测对变化的抵抗力；和/或b)是可逆的。为了实现这一目标，我们将使用脑成像技术来分析在经过充分验证的父母训练干预之前和之后的CP儿童的大脑，这已经被证明可以有效地减少CP儿童的反社会行为。如果成功，我们的工作将帮助我们：a)更好地理解脑瘫的大脑异常和反社会行为之间的关系；b)确定为什么有些脑瘫儿童的反社会行为比其他儿童更抗拒改变。预计我们的发现也将有助于未来研究CP的分子基础，并最终导致更好的治疗方法。

Children with conduct problems (CP) are repetitively and persistently aggressive, destructive and break rules in social and school settings. Understanding the cause(s) of CP is important as these children are much more likely to have continued problems in adult life. This includes alcoholism, drug abuse, mental illness, criminality, domestic violence, unemployment and early death. They also cost society billions of pounds each year and have significant emotional costs on their victims.The underlying cause(s) for CP is probably complex but there is compelling evidence that children with CP have differences in brain anatomy and function. However, no-one has analysed whether there are specific brain differences that: a) predict resistance to change; and/or b) are 'reversible'. To achieve this we will use brain imaging techniques to analyse the brain in CP children before and after a well-validated parent training intervention, which has been demonstrated to effectively reduce antisocial behaviour in CP children.If successful, our work will help us to: a) better understand the relationship between brain abnormalities in CP and antisocial behaviour and b) identify why antisocial behaviour in some children with CP is more resistant to change than others.It is also anticipated that our findings will also assist in focusing future research into the molecular basis of CP, and ultimately lead to better treatments.