PHASE I/II CHEMOPREVENTION OF DFMO IN SUBJECTS AT RISK FOR COLORECTAL CANCER

DFMO 对结直肠癌高危人群的 I/II 期化学预防

• 批准号: 5224582
• 负责人: RICHARD R LOVE
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5224582
• 关键词: cancer prevention; chemoprevention; clinical research; clinical trial phase I; colorectal neoplasms; difluoromethylornithine; enzyme activity; human subject; human therapy evaluation; neoplasm /cancer chemotherapy; ornithine decarboxylase; polyamines

The overall goal of this project is to determine whether difluoromethylornithine (DFMO) 0.5 g/m2 per day significantly suppresses polyamine and ornithine decarboxylase activity levels in colorectal tissues.

该项目的总体目标是确定是否 二氟甲基鸟氨酸 (DFMO) 每天 0.5 g/m2 显着抑制多胺和鸟氨酸 结直肠组织中的脱羧酶活性水平。