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INTERFERON GAMMA (IND #BB-3368) TREATMENT OF OSTEOPETROSIS

INTERFERON GAMMA (IND #BB-3368) TREATMENT OF OSTEOPETROSIS
γ 干扰素(IND
批准号:
5222346
负责人:
L. LYNDON KEY
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
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英文摘要
Prior study has provided data suggesting that interferon gamma 1b improves ne resorption, yielding an increase in bone marrow space; improves white cell super-oxide production, and reduces the trend toward progressive narrowing the cranial nerve foramina. This study proposes to determine if interferon gam 1b therapy combined with calcitriol can improve bone turnover, marrow function and the size of cranial nerve foramina in severe osteopetrosis to a greater ext t than calcitriol alone through a randomized, controlled, open-label trial.
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