MICA: Ancestry and biological Informative Markers for stratification of HYpertension: The AIM HY study

MICA：高血压分层的祖先和生物信息标记：AIM HY 研究

• 批准号: MR/M016560/1
• 负责人: Phil Chowienczyk
• 金额: $ 446.6万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM016560%2F1
• 关键词: MICA; Ancestry; biological; Informative; Markers

High blood pressure (hypertension) is extremely common within the general population in the UK and worldwide and is a major cause of heart disease, kidney disease and stroke. It is recognised to be the single biggest contributor to the global burden of disease. In most people with hypertension, a healthy lifestyle alone is not enough to control blood pressure, and drug treatment is required. There are a wide variety of drugs available and although these are effective and safe, it is often necessary to try different types of drugs and often to use a combination of two or more drugs. Delay in choosing the right kind of tablet or combination of tablets through "trial and error" is a major problem and, in a large proportion of people with hypertension, blood pressure is not adequately controlled. Relatively little is known about why some people respond better to one kind of tablet or combination of tablets than others. It is know that response to treatment differs in different ethnic groups in the UK and may differ between populations in Europe, Asia and Africa. The objective of this research proposal is to determine if we can use genetic markers of ancestry (which predict the proportion of a person's ancestors from Europe, Asia and Africa) and a detailed measure of chemical "metabolites" circulating in the blood that characterise the biochemical processes in each person to predict the best type of drug or combination of drugs for that person. If a combination of drugs is required we can use a new technology to put these into a single tablet. We hope that this will provide a more effective simpler approach to single tablet treatment of hypertension both in the UK and in other countries.

高血压在英国和世界各地的普通人群中极为常见，是心脏病、肾病和中风的主要原因。它被认为是造成全球疾病负担的最大单一因素。对于大多数高血压患者来说，仅靠健康的生活方式不足以控制血压，还需要药物治疗。可用的药物种类繁多，尽管这些药物有效且安全，但通常需要尝试不同类型的药物，并且通常需要组合使用两种或多种药物。通过“反复试验”延迟选择正确的片剂或片剂组合是一个主要问题，并且在很大一部分高血压患者中，血压没有得到充分控制。对于为什么有些人对一种平板电脑或平板电脑组合的反应比其他人更好，人们知之甚少。众所周知，英国不同种族群体对治疗的反应不同，欧洲、亚洲和非洲人群对治疗的反应也可能不同。这项研究计划的目的是确定我们是否可以使用祖先的遗传标记（预测一个人的祖先来自欧洲、亚洲和非洲的比例）以及血液中循环的化学“代谢物”的详细测量（表征每个人的生化过程）来预测对该人的最佳药物类型或药物组合。如果需要组合药物，我们可以使用新技术将它们放入单一药片中。我们希望这将为英国和其他国家的高血压单片治疗提供一种更有效、更简单的方法。

项目成果

Genetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization

• DOI: 10.1093/eurheartj/ehaa238
• 发表时间: 2020-09-14
• 期刊: EUROPEAN HEART JOURNAL
• 影响因子: 39.3
• 作者: Cecelja, Marina;Keehn, Louise;Chowienczyk, Phil
• 通讯作者: Chowienczyk, Phil

Monotherapy With Major Antihypertensive Drug Classes and Risk of Hospital Admissions for Mood Disorders.

• DOI: 10.1161/hypertensionaha.116.08188
• 发表时间: 2016-11
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Boal AH;Smith DJ;McCallum L;Muir S;Touyz RM;Dominiczak AF;Padmanabhan S
• 通讯作者: Padmanabhan S

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.

• DOI: 10.1038/s41591-020-01183-8
• 发表时间: 2021-03
• 期刊: Nature medicine
• 影响因子: 82.9
• 作者: Asnicar F;Berry SE;Valdes AM;Nguyen LH;Piccinno G;Drew DA;Leeming E;Gibson R;Le Roy C;Khatib HA;Francis L;Mazidi M;Mompeo O;Valles-Colomer M;Tett A;Beghini F;Dubois L;Bazzani D;Thomas AM;Mirzayi C;Khleborodova A;Oh S;Hine R;Bonnett C;Capdevila J;Danzanvilliers S;Giordano F;Geistlinger L;Waldron L;Davies R;Hadjigeorgiou G;Wolf J;Ordovás JM;Gardner C;Franks PW;Chan AT;Huttenhower C;Spector TD;Segata N
• 通讯作者: Segata N

Immunoglobulin G glycome composition in transition from premenopause to postmenopause.

• DOI: 10.1016/j.isci.2022.103897
• 发表时间: 2022-03-18
• 期刊: iScience
• 影响因子: 5.8
• 作者: Deriš H;Kifer D;Cindrić A;Petrović T;Cvetko A;Trbojević-Akmačić I;Kolčić I;Polašek O;Newson L;Spector T;Menni C;Lauc G
• 通讯作者: Lauc G

Human postprandial responses to food and potential for precision nutrition.

• DOI: 10.1038/s41591-020-0934-0
• 发表时间: 2020-06
• 期刊: Nature medicine
• 影响因子: 82.9
• 作者: Berry SE;Valdes AM;Drew DA;Asnicar F;Mazidi M;Wolf J;Capdevila J;Hadjigeorgiou G;Davies R;Al Khatib H;Bonnett C;Ganesh S;Bakker E;Hart D;Mangino M;Merino J;Linenberg I;Wyatt P;Ordovas JM;Gardner CD;Delahanty LM;Chan AT;Segata N;Franks PW;Spector TD
• 通讯作者: Spector TD