Multi-omics study of ancestry enriched associations in Hispanics/Latinos

西班牙裔/拉丁裔血统丰富关联的多组学研究

基本信息

批准号：
10889299
负责人：
Nora Franceschini
金额：
$ 35万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-21 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10889299
关键词：
APOL1 gene Address Admixture African African ancestry Amino Acids Biological Process Biological Products Cardiometabolic Disease Cardiovascular Diseases Chromosomes Chronic Disease Chronic Kidney Failure Clinical Clinical Data Complement Complex Data Diabetes Mellitus Diagnosis Disease Disease susceptibility Environmental Exposure European Frequencies Gene Frequency Genes Genetic Genetic Risk Genome Genomic Segment Genomics Genotype Goals Health Healthcare Hispanic Community Health Study/Study of Latinos Hispanic Populations Human Individual Inflammatory Inherited Kidney Kidney Diseases Knowledge Latino Population Lipids Maps Measures Mendelian randomization Metabolic Metabolic Diseases Metabolism Minority Groups Mission Molecular Multiomic Data National Human Genome Research Institute Native American Ancestry Native Americans Obesity Participant Pathway interactions Physiological Population Populations at Risk Process Proteins Proteomics Public Health Research Signal Transduction Single Nucleotide Polymorphism Source Susceptibility Gene Testing Trans-Omics for Precision Medicine Variant Whole Blood admixture mapping cardiometabolism clinical biomarkers clinical care clinical phenotype clinical translation clinically relevant cohort disorder risk ethnic minority fatty liver disease genetic association genetic variant genome wide association study genome-wide genomic data improved insight metabolomics mortality multi-ethnic multiple omics novel strategies personalized medicine population based programs protein biomarkers racial minority rare variant social culture trait transcriptome sequencing transcriptomics

项目摘要

ABSTRACT This proposal builds into our ongoing research in genetics and disease risk in admixed Hispanic populations. Hispanics/Latinos are the larger racial/ethnic minority in the U.S. They have a high burden of cardiometabolic and inflammatory related diseases. Genetically, Hispanics are an heterogenous population comprised of multiple ancestral groups (primarily Native American, West African, European) from recent admixture. Few studies have leveraged genetic ancestry to address differences in disease susceptibility. This study will leverage the comprehensive data from the large population-based Hispanic Community Health Study/Study of Latinos for discovery of ancestry-enriched susceptibility loci. We propose to integrate genomics and multi- omics data to map genomic segments and variants inherited from the ancestral population with the higher disease variant frequency (Aim 1), use new approaches for fine-mapping genomic regions (Aim 2), and validate our findings for clinical relevance in Hispanics/Latinos from the All of Us study (Aim 3). We expect to gain insights into the identified ancestry-related genomic regions and variants and their relationship to disease states. This proposal uniquely complements large ongoing genome wide association approaches. Our results may provide insights into differences in disease risk in admixed populations. Ultimately this research could inform personalized medicine and improve public health.

抽象的这项提议融入了我们正在进行的对掺杂西班牙裔人群的遗传学和疾病风险的研究。西班牙裔/拉丁美洲人是美国较大的种族/族裔少数民族，他们的心脏代谢负担很高和相关疾病。从遗传上讲，西班牙裔是由来自最近的混合物的多个祖先（主要是美国原住民，西非，欧洲）。很少研究利用遗传血统来解决疾病易感性的差异。这项研究会利用大型基于人群的西班牙裔社区健康研究/研究的全面数据拉丁美洲人发现富含祖先的易感基因座。我们建议整合基因组学和多重 OMIC数据以绘制从祖先种群继承的基因组细分和变体，疾病变异频率（AIM 1），使用新方法进行精细映射基因组区域（AIM 2），而验证我们从我们所有人学习的西班牙裔/拉丁裔临床相关性的发现（AIM 3）。我们希望洞悉与祖先相关的基因组区域和变体及其与疾病的关系国家。该提案独特地补充了大型持续的基因组广泛关联方法。我们的结果可能会提供有关混合种群中疾病风险差异的见解。最终这项研究可能告知个性化医学并改善公共卫生。