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EFFECT OF IGF-1 ON MALNOURISHED CHILDREN WITH CYSTIC FIBROSIS

EFFECT OF IGF-1 ON MALNOURISHED CHILDREN WITH CYSTIC FIBROSIS
IGF-1 对患有囊性纤维化的营养不良儿童的影响
批准号：
5225659
负责人：
JOHN C BUCUVALAS
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5225659
关键词：
child (0-11) child physical development clinical research cystic fibrosis hormone regulation /control mechanism hormone therapy human subject human therapy evaluation insulinlike growth factor malabsorption malnutrition nutrition related tag respiratory function

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英文摘要
Malnutrition in children with cystic fibrosis (CF), results from a complex interaction of chronic pulmonary disease, increased energy expenditure, malabsorption, and recurrent infection. Growth-stimulating peptides promote anabolism in nutritionally compromised patients. Our goal is to test the following hypothesis: Treatment with insulin-like growth factor-I (IGF-1), which subserves the anabolic properties of growth hormone, will result in enhanced linear growth, increased lean body mass and improved lung function in nutritionally compromised children with CF.
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Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant
  • 批准号：
    7829439
  • 项目类别：
  • 资助金额：
    $47.79万
  • 财政年份：
    2009
  • 负责人：
    JOHN C BUCUVALAS
  • 依托单位：
    CHILDREN'S HOSP OF PHILADELPHIA
Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant
  • 批准号：
    7942967
  • 项目类别：
  • 资助金额：
    $48.1万
  • 财政年份：
    2009
  • 负责人：
    JOHN C BUCUVALAS
  • 依托单位：
    CHILDREN'S HOSP OF PHILADELPHIA
BILIARY ATRESIA RESEARCH CONSORTIUM DATABASE
BILIARY ATRESIA STUDY (BASIC)