EFFECT OF IGF-1 ON MALNOURISHED CHILDREN WITH CYSTIC FIBROSIS

我们的目标是确定用胰岛素样生长因子治疗 IGF-I改善营养状况，促进营养不良儿童的生长 患有囊性纤维化的儿童 我们正处于第一阶段和第二阶段 一项比较IGF-I与安慰剂治疗的盲交叉研究， 营养不良的CF患者。 营养不良对生存有不利影响 并且在具有恶化的肺功能的CF患者中普遍存在， 功能 营养补充剂通常需要使用 胃造口术或鼻胃管。 然而，喂养是困难的， 管理，并可能进一步羞辱儿童和青少年与CF。 IGF-I是一种生长促进肽， 正常生长，在患有CF的儿童和青少年中很低。 以来 IGF-I治疗可改善营养不良者的营养状况 患者，存在评估促生长治疗的基本原理 营养不良的CF儿童中的肽。 此外，委员会认为， IGF-I有助于调节血糖水平。 IGF-I对血液的影响 血糖控制可能特别重要，因为CF患者 患糖尿病的风险增加。 如果IGF-I改善了营养 状态，生长和葡萄糖控制，那么它可能会增强 CF营养不良儿童的功能结局。

Our goal is to determine if treatment with insulin-like growth factor (IGF-I) improves nutritional status and promotes growth in undernourished children with cystic fibrosis. We are in the midst of a phase 1-2 double blind crossover study that compares the treatment with IGF-I to placebo in undernourished patients with CF. Malnutrition adversely affects survival and is prevalent among patients with CF who have deteriorating pulmonary function. Nutritional supplementation often requires the use of a gastrostomy or nasogastric tube. However, the feedings are difficult to administer and may further stigmatize children and adolescents with CF. Blood levels of IGF-I, a growth-promoting peptide that is necessary for normal growth, are low in children and adolescents with CF. Since treatment with IGF-I improves nutritional status in undernourished patients, a rationale exists to assess treatment with growth-promoting peptides in those children with CF who are undernourished. Furthermore, IGF-I helps to regulate blood sugar levels. The effect of IGF-I on blood glucose control may be of particular importance since patients with CF have an increased risk to develop diabetes. If IGF-I improves nutritional status, growth, and glucose control, then it will likely enhance functional outcome in undernourished children with CF.