EFFECT OF IGF-1 ON MALNOURISHED CHILDREN WITH CYSTIC FIBROSIS

IGF-1 对患有囊性纤维化的营养不良儿童的影响

• 批准号: 6309935
• 负责人: JOHN C BUCUVALAS
• 金额: $ 2.85万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6309935
• 关键词: blood glucose; child (0-11); child physical development; clinical research; clinical trial phase I; cystic fibrosis; developmental nutrition; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; insulinlike growth factor; malabsorption; malnutrition; nutrition related tag; respiratory function

Our goal was to determine if treatment with insulin-like growth factor (IGF-I) improves nutritional status and promotes growth in undernourished children with cystic fibrosis. We are in the midst of a phase 1-2 double blind crossover study that compares the treatment with IGF-I to placebo in undernourished patients with CF. Malnutrition adversely affects survival and is prevalent among patients with CF who have deteriorating pulmonary function. Nutritional supplementation often requires the use of a gastrostomy or nasogastric tube. However, the feedings are difficult to administer and may further stigmatize children and adolescents with CF. Blood levels of IGF-I, a growth-promoting peptide that is necessary for normal growth, are low in children and adolescents with CF. Since treatment with IGF-I improves nutritional status in undernourished patients, a rationale exists to assess treatment with growth-promoting peptides in those children with CF who are undernourished. Furthermore, IGF-I helps to regulate blood sugar levels. The effect of IGF-I on blood glucose control may be of particular importance since patients with CF have an increased risk to develop diabetes. If IGF-I improves nutritional status, growth, and glucose control, then it will likely enhance functional outcome in undernourished children with CF.

我们的目标是确定胰岛素样生长因子 (IGF-I) 治疗是否可以改善患有囊性纤维化的营养不良儿童的营养状况并促进生长。 我们正在进行一项 1-2 期双盲交叉研究，该研究将 IGF-I 与安慰剂对营养不良 CF 患者的治疗进行比较。 营养不良会对生存产生不利影响，并且在肺功能恶化的 CF 患者中普遍存在。 营养补充通常需要使用胃造口术或鼻胃管。 然而，喂养很难进行，并且可能进一步使患有囊性纤维化的儿童和青少年蒙受耻辱。 IGF-I（一种正常生长所必需的促生长肽）的血液水平在患有 CF 的儿童和青少年中较低。 由于 IGF-I 治疗可改善营养不良患者的营养状况，因此有理由评估营养不良的 CF 儿童的生长促进肽治疗。 此外，IGF-I 有助于调节血糖水平。 IGF-I 对血糖控制的影响可能特别重要，因为 CF 患者患糖尿病的风险增加。 如果 IGF-I 改善营养状况、生长和血糖控制，那么它可能会增强患有 CF 的营养不良儿童的功能结果。