SOMATOSENSORY EVOKED POTENTIALS (SEP) IN CERVICAL SPINAL CORD COMPRESSION

本研究使用体感诱发电位(SEPS)来 50例颈椎手术患者的脊髓功能评估 解压。这项研究的主要目标是确定 术前、术中、术后体感诱发电位的关系 以及颈髓术后患者的神经转归 解压。另一个关注的焦点是团注和 持续输注肌松药(维库溴铵)治疗 SEPS。术前，患者将接受标准化的 神经学检查，以及诱发电位记录。这个 手腕的正中神经将被刺激并锁骨(ERb‘s)， 颈部(C2和C7)和皮质(对侧皮质)诱发 势能将会被获得。录音将在再培训局的 和对侧皮质。在获得基线记录后，一组 (n=25)静脉推注维库溴铵(0。1 mg/kg)，以及 另一组(N=25)接受持续输液(0.9-1 .7微克/公斤/分钟)的维库溴铵。十 服用维库溴铵几分钟后，SEP将被记录在 每组。SEP将在关键阶段进行监测和评估， 以及在手术程序结束时。三个月 术后将进行另一组SEPS检查。该协议将 与手术前的完全相同。患者还将接受 后续的神经学检查。

The present investigation uses Somatosensory Evoked Potentials (SEPs) to assess spinal cord function in 50 patients undergoing cervical decompression. The primary objective of this study is to determine the relationship between preoperative, intraoperative and postoperative SEPs, and the neurological outcome of patients following cervical spinal cord decompression. An additional focus is on the effect of bolus and continuous infusion of muscle relaxants (vercuronium bromide) on the SEPs. Preoperatively, the patients will undergo a standardized neurological examination, as well as an evoked potentials recording. The median nerve at the wrist will be stimulated and clavicular (Erb's), cervical (C2 and C7), and cortical (contralateral cortex) evoked potentials will be obtained. The recordings will be taken at the Erb's and contralateral cortex. After baseline recording is obtained, one group (N=25) will receive an intravenous bolus of vercuronium (0. 1mg/kg), and the other group (N=25) will receive continuous infusion (0.9-1 .7ug/kg/min) of vercuronium during their operative procedures. Ten minutes after administration of vercuronium, SEPs will be recorded in each group. SEPs will be monitored and evaluated during essential stages, as well as at the end of the operative procedures. Three months postoperatively another set of SEPs will be performed. The protocol will be identical with the preoperative one. The patients also will undergo a follow up neurological examination.