Newton001 Leishmaniasis in the Brazilian Amazon: the role of accessory microbiota in disease progression, pathobiology and immunity.

Newton001 巴西亚马逊地区的利什曼病：辅助微生物群在疾病进展、病理学和免疫中的作用。

• 批准号: MR/M026353/1
• 负责人: Christopher Quince
• 金额: $ 4.81万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM026353%2F1
• 关键词: Newton001; Leishmaniasis; Brazilian; Amazon; role

Leishmania spp. infection represents a serious public health burden in Brazil, with 35,000 suspected cases annually. Disfiguring and occasionally fatal cutaneous and muco-cutaneous forms of Leishmaniasis are most common in the Amazon region of Brazil. Differential clinical severity and drug-resistance profiles are widely reported between patients. There is thus an urgent need to identify what factors might be responsible for different patient outcomes. Leishmania species and genotype have a role in defining disease severity, as does the host immune response. Less commonly considered is the role that secondary bacterial infections and commensal skin microbiota have in modulating pathology and immunity. In this multidisciplinary project we propose to use state-of-the-art techniques to monitor Leishmania lesion-associated microbial diversity and host immune response to reveal the factors that underlie cutaneous Leishmaniasis severity and progression in Amazonian Brazil.

利什曼感染是巴西严重的公共卫生负担，每年有35 000例疑似病例。毁容和偶尔致命的皮肤和粘膜皮肤形式的利什曼病在巴西亚马逊地区最常见。不同的临床严重程度和耐药性特征在患者之间被广泛报道。因此，迫切需要确定哪些因素可能导致不同的患者结局。利什曼原虫属和基因型在确定疾病严重程度方面发挥作用，宿主免疫反应也是如此。较少被考虑的是继发性细菌感染和皮肤微生物群在调节病理和免疫中的作用。在这个多学科的项目中，我们建议使用最先进的技术来监测利什曼原虫病损相关的微生物多样性和宿主免疫反应，以揭示巴西亚马逊地区皮肤利什曼病严重程度和进展的因素。

项目成果

Colonization and genetic diversification processes of Leishmania infantum in the Americas.

• DOI: 10.1038/s42003-021-01658-5
• 发表时间: 2021-01-29
• 期刊: Communications biology
• 影响因子: 5.9
• 作者: Schwabl P;Boité MC;Bussotti G;Jacobs A;Andersson B;Moreira O;Freitas-Mesquita AL;Meyer-Fernandes JR;Telleria EL;Traub-Csekö Y;Vaselek S;Leštinová T;Volf P;Morgado FN;Porrozzi R;Llewellyn M;Späth GF;Cupolillo E
• 通讯作者: Cupolillo E