Newton001: Brazil-UK collaboration in Health Technology Assessment of diagnostic strategies for infectious diseases

Newton001：巴西与英国在传染病诊断策略卫生技术评估方面的合作

• 批准号: MR/M026515/1
• 负责人: Christopher Hyde
• 金额: $ 9.18万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM026515%2F1
• 关键词: Newton001; Brazil; UK; collaboration; Health

This project is primarily about improving the number of people with good research skills through a scientific partnership between the University of Exeter and the Oswaldo Cruz Foundation (Fiocruz). Together we will do this by passing on established methods of health technology assessment, particularly health economic modelling. Health technology assessment involves identifying the benefits and harms of any new approach to health care, particularly whether the costs of introducing the new technology seem justified. We will also attempt to improve health technology assessment in an area of common interest, new diagnostic tests for the identification of infectious disease and complications arising from them. In contrast to disease treatments, approaches to evaluating the effectiveness and cost-effectiveness of tests designed to improve our ability to identify whether someone has a particular disease such as hepatitis are at an earlier stage of development. From the perspective of the UK, this project will help the University of Exeter appreciate the challenges of doing health technology assessment outside the UK. As well teaching the techniques of health technology assessment, we will improve research skills by jointly working on a specific assessment comparing the impact of two different non-invasive diagnostic methods - AST to Platelet Ratio Index (APRI) and transient elastography (FibroScan) - to monitor whether liver scarring is beginning, getting worse or better in people living with Hepatitis C. There will be reciprocal visits and regular communication between both centres to these ends during 2015.

该项目主要是通过埃克塞特大学和奥斯瓦尔多·克鲁兹基金会（Fiocruz）之间的科学合作伙伴关系来提高具有良好研究技能的人数。为此，我们将共同传递卫生技术评估的既定方法，特别是卫生经济模型。卫生技术评估涉及确定任何新的卫生保健方法的利弊，特别是引进新技术的成本是否合理。我们还将努力在一个共同关心的领域改进卫生技术评估，即用于查明传染病及其引起的并发症的新诊断测试。与疾病治疗相比，评估测试的有效性和成本效益的方法，旨在提高我们识别某人是否患有某种特定疾病（如肝炎）的能力，尚处于较早的发展阶段。从英国的角度来看，这个项目将帮助埃克塞特大学认识到在英国以外进行卫生技术评估的挑战。在教授卫生技术评估技术的同时，我们将通过联合开展一项具体评估，比较两种不同的非侵入性诊断方法——AST与血小板比率指数（APRI）和瞬时弹性成像（FibroScan）——对监测肝脏瘢痕形成是否开始的影响，从而提高研究技能。在2015年期间，两个中心将为此目的进行互访和定期沟通。

项目成果

Additional file 1: of Age-standardized mortality rates related to viral hepatitis in Brazil

附加文件 1：巴西与病毒性肝炎相关的年龄标准化死亡率

• DOI: 10.6084/m9.figshare.c.3840109_d1
• 发表时间: 2017
• 作者: Perazzo H

Cost-effectiveness of diagnostic and therapeutic interventions for chronic hepatitis C: a systematic review of model-based analyses.

• DOI: 10.1186/s12874-018-0515-9
• 发表时间: 2018-06-13
• 期刊: BMC medical research methodology
• 影响因子: 4
• 作者: Castro R;Crathorne L;Perazzo H;Silva J;Cooper C;Varley-Campbell J;Marinho DS;Haasova M;Veloso VG;Anderson R;Hyde C
• 通讯作者: Hyde C

Micro-costing analysis of guideline-based treatment by direct-acting agents: the real-life case of hepatitis C management in Brazil.

• DOI: 10.1186/s12876-017-0676-8
• 发表时间: 2017-11-23
• 期刊: BMC gastroenterology
• 影响因子: 2.4
• 作者: Perazzo H;Jorge MJ;Silva JC;Avellar AM;Silva PS;Romero C;Veloso VG;Mujica-Mota R;Anderson R;Hyde C;Castro R
• 通讯作者: Castro R

Age-standardized mortality rates related to viral hepatitis in Brazil.

• DOI: 10.1186/s12879-017-2619-y
• 发表时间: 2017-07-31
• 期刊: BMC infectious diseases
• 影响因子: 3.7
• 作者: Perazzo H;Pacheco AG;Luz PM;Castro R;Hyde C;Fittipaldi J;Rigolon C;Cardoso SW;Grinsztejn B;Veloso VG
• 通讯作者: Veloso VG

Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective.

• DOI: 10.1155/2015/852968
• 发表时间: 2015
• 期刊: International journal of hepatology
• 影响因子: 1.8
• 作者: Castro R;Perazzo H;Grinsztejn B;Veloso VG;Hyde C
• 通讯作者: Hyde C