Developing novel anti-cancer agens by high throughput chemical screens for small molcules that modulate the pro-survival

癌症是我们社区第二常见的死亡原因。不幸的是，治疗经常失败或引起不想要的副作用。这项提议寻求发现和开发一类新的抗癌药物，这些药物通过直接激活程序性细胞死亡(细胞凋亡)发挥作用。Bcl2蛋白是细胞死亡的关键调节因子，通过利用这些癌症治疗的主要靶点的知识，我们的目标是发现具有相当大的医疗和商业价值的药物。

Cancer is the second commonest cause of deaths in our community. Unfortunately, treatment often fails or causes unwanted side effects. This proposal seeks to discover and develop a novel class of anti-cancer drugs that act by directly activating programmed cell death (apoptosis). The Bcl-2 proteins are key regulators of cell death and by exploiting knowledge about these prime targets for cancer therapy, we aim to discover drugs that are potentially of considerable medical and commercial value.