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High-Throughput Discovery of Synergistic Drug Combinations for Metastatic Colorectal Cancer

High-Throughput Discovery of Synergistic Drug Combinations for Metastatic Colorectal Cancer
高通量发现转移性结直肠癌的协同药物组合
批准号：
nhmrc : GNT1079362
负责人：
A/Pr Ian Street
金额：
$147.02万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 --
来源：
https://researchdata.edu.au/high-throughput-discovery-colorectal-cancer/1345278
关键词：
ThroughputDiscoverySynergisticDrugCombinations

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英文摘要
Treatment outcomes for patients with metastatic bowel cancer remain poor, with most tumours developing resistance within 24 months. A key problem is that cancers are genetically diverse, with some cells inevitably resistant to any given treatment. This study aims to discover effective drug combinations targeting distinct essential tumour cell functions through robotics-based pairwise testing of known drugs on bowel cancer cell lines representing the genetic diversity of the disease.
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Multidrug Resistance Protein 1 inhibitors to sensitise cancers to chemotherapy
  • 批准号：
    nhmrc : 1136278
  • 项目类别：
    Development Grants
  • 资助金额：
    $56.81万
  • 财政年份：
    2018
  • 负责人：
    A/Pr Ian Street
  • 依托单位：
    The University of New South Wales
Multidrug Resistance Protein 1 inhibitors to sensitise cancers to chemotherapy
  • 批准号：
    nhmrc : GNT1136278
  • 项目类别：
    Development Grants
  • 资助金额：
    $84.02万
  • 财政年份：
    2018
  • 负责人：
    A/Pr Ian Street
  • 依托单位：
High-Throughput Discovery of Synergistic Drug Combinations for Metastatic Colorectal Cancer
Role of MACROD2 Loss in DNA Repair, Chromosomal Instability and Development of Colorectal Cancer: Clinical and Therapeutic Implications
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