The EPIC-Norfolk prospective population study: biological and behavioural determinants of health and disease in an ageing population

EPIC-诺福克前瞻性人口研究：老龄化人口中健康和疾病的生物和行为决定因素

• 批准号: MR/N003284/1
• 负责人: Kay-Tee Khaw
• 金额: $ 237.51万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN003284%2F1
• 关键词: EPIC; Norfolk; prospective; population; study

The aim of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) is to help us understand what we can do to improve health and prevent disease and disability in later life. There is a particular focus on patterns of diet and physical activity. EPIC-Norfolk is a study of 30,000 men and women living in Norfolk who first agreed to take part in the study in 1993 when aged 40-79 years of whom 25,00 attended a detailed health examination and who have been followed up to the present for health. At the original health examination in 1993-1997 they gave detailed information on their health and lifestyle, including very detailed diet and physical activity records, medical and family history, had assessments of heart disease risk factors including blood cholesterol and blood pressure, and provided blood and urine samples for analysis. Participants have continued to take part in repeated health assessments with further measures to assess bone health, eye health and visual function, and physical and mental performance, the most recent being between 2006-2011, and answered further questionnaires about their health including psychosocial factors such as stress and anxiety, sleep patterns and quality of life. We have thus been able to track the health experiences over 20 years of this middle aged older population who are comparable to the British general population. We are able to obtain an understanding of the risk factors for important diseases such as heart diseases and strokes, individual cancers, osteoporotic fractures, arthritis and diabetes and what we can do to reduce risk of these diseases. As the population ages, there is increasing emphasis on outcomes relevant to older people, not just disease occurrence and death, but functional capacity including physical function, mental function, visual health as well as self perceived quality of life. The detailed data available enable us to understand not just how the mind and body age biologically, but behavioural factors such as diet and physical activity may affect this process and how wider environmental determinants such as socioeconomic status, residential deprivation and access to green space can influence our health. This is an ongoing population study and have an active participants' panel that advises us on research questions of interest and future studies. Results from the study have already contributed to health policy and recommendations including a Department of Health Public Health initiative"Small changes Big difference". We have now been able to conduct genetic profiling of the participants to enable us to identify how our genetic make up can influence risk of disease and will explore how environmental factors such as health behaviours may modify genetic susceptibility. The current application is to maintain follow up of participants and assessments to understand how different individuals may age differently and further clarify what factors influence the ageing process and risk of disease and disability to enable interventions to improve health and quality of life.

欧洲诺福克癌症前瞻性调查 (EPIC-Norfolk) 的目的是帮助我们了解如何在晚年改善健康并预防疾病和残疾。特别关注饮食和身体活动的模式。 EPIC-Norfolk 是一项针对居住在诺福克的 30,000 名男性和女性的研究，他们于 1993 年首次同意参加这项研究，当时年龄在 40-79 岁之间，其中 25,000 人参加了详细的健康检查，并一直随访至今。在1993年至1997年的最初健康检查中，他们提供了有关其健康和生活方式的详细信息，包括非常详细的饮食和体力活动记录、医疗和家族史，对包括血液胆固醇和血压在内的心脏病危险因素进行了评估，并提供了血液和尿液样本进行分析。参与者继续参加重复的健康评估，进一步采取措施评估骨骼健康、眼睛健康和视觉功能以及身心表现，最近一次是在2006年至2011年之间，并回答了有关其健康的进一步调查问卷，包括压力和焦虑等社会心理因素、睡眠模式和生活质量。因此，我们能够追踪这个中年老年人口20多年来的健康经历，与英国普通人口相当。我们能够了解心脏病和中风、个体癌症、骨质疏松性骨折、关节炎和糖尿病等重要疾病的危险因素，以及我们可以采取哪些措施来降低这些疾病的风险。随着人口老龄化，人们越来越重视与老年人相关的结果，不仅仅是疾病的发生和死亡，还包括身体功能、心理功能、视觉健康以及自我感知的生活质量等功能能力。现有的详细数据不仅使我们能够了解身心如何在生物学上老化，而且饮食和身体活动等行为因素可能会影响这一过程，以及社会经济地位、居住剥夺和绿地使用等更广泛的环境决定因素如何影响我们的健康。这是一项正在进行的人口研究，有一个活跃的参与者小组，可以就感兴趣的研究问题和未来的研究向我们提供建议。该研究的结果已经为卫生政策和建议做出了贡献，包括卫生部公共卫生倡议“小变化大差异”。我们现在已经能够对参与者进行基因分析，使我们能够确定我们的基因组成如何影响疾病风险，并将探索健康行为等环境因素如何改变遗传易感性。 当前的应用程序是对参与者进行跟踪和评估，以了解不同个体的衰老情况有何不同，并进一步阐明哪些因素影响衰老过程以及疾病和残疾的风险，以便采取干预措施来改善健康和生活质量。

项目成果

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.

• DOI: 10.1158/1055-9965.epi-18-0079
• 发表时间: 2019-01
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Adams CD;Richmond R;Ferreira DLS;Spiller W;Tan V;Zheng J;Würtz P;Donovan J;Hamdy F;Neal D;Lane JA;Smith GD;Relton C;Eeles RA;Haiman CA;Kote-Jarai Z;Schumacher FR;Olama AAA;Benlloch S;Muir K;Berndt SI;Conti DV;Wiklund F;Chanock SJ;Gapstur S;Stevens VL;Tangen CM;Batra J;Clements JA;Gronberg H;Pashayan N;Schleutker J;Albanes D;Wolk A;West CML;Mucci LA;Cancel-Tassin G;Koutros S;Sorensen KD;Maehle L;Travis RC;Hamilton RJ;Ingles SA;Rosenstein BS;Lu YJ;Giles GG;Kibel AS;Vega A;Kogevinas M;Penney KL;Park JY;Stanford JL;Cybulski C;Nordestgaard BG;Brenner H;Maier C;Kim J;John EM;Teixeira MR;Neuhausen SL;De Ruyck K;Razack A;Newcomb LF;Lessel D;Kaneva RP;Usmani N;Claessens F;Townsend PA;Dominguez MG;Roobol MJ;Menegaux F;Khaw KT;Cannon-Albright LA;Pandha H;Thibodeau SN;Martin RM;PRACTICAL consortium
• 通讯作者: PRACTICAL consortium

Prediction of acute myeloid leukaemia risk in healthy individuals

健康个体急性髓性白血病风险的预测

• DOI: 10.17863/cam.30393
• 发表时间: 2018
• 作者: Abelson S

Prediction of acute myeloid leukaemia risk in healthy individuals.

在健康个体中预测急性髓样白血病的风险。

• DOI: 10.1038/s41586-018-0317-6
• 发表时间: 2018-07
• 期刊: Nature
• 影响因子: 64.8
• 作者: Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
• 通讯作者: Shlush LI

Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.

体力活动、中介因素和结肠癌风险：EPIC 队列对肥胖和循环生物标志物的见解。

• DOI: 10.17863/cam.18775
• 发表时间: 2017
• 作者: Aleksandrova K