Urinary sugars as biomarker for dietary sugar intake; a prospective population study

虽然人们普遍认为，从饮食中摄入大量的糖对健康有害，但令人惊讶的是，很少有科学证据支持这一点。这可能与我们难以测量膳食糖摄入量有关，因为它在食物中广泛存在且含量不一。我们的工作表明，尿液中的糖排泄（蔗糖和果糖）（而不是葡萄糖，这可能表明糖尿病）是膳食糖摄入量的良好反映。我们建议研究饮食中糖的摄入量是否与老年慢性疾病的长期风险有关，如心脏病，中风和糖尿病，年龄在40-79岁之间的25，000名男性和女性，他们在1993年至今接受了健康随访。这可能有助于我们更好地了解如何预防与衰老相关的慢性疾病。

Though it is commonly believed that a high dietary intake of sugar is bad for health, there is surprisingly little scientific evidence to support this. This may relate to our difficulty in measuring dietary sugar intake given its widespread presence and variable amounts in foods. Our work suggests that sugar excretion (sucrose and fructose) in the urine (as opposed to glucose, which is may indicate diabetes) is a good reflection of dietary sugar intake. We propose to examine whether dietary sugar intake, as assessed using urine sugar excretion is related to long term risk of chronic diseases associated with ageing such as heart disease, stroke and diabetes in 25,000 men and women aged 40-79 who have been followed up between 1993 to the present for health. This may help us understand better how to prevent chronic diseases associated with ageing.