Diet, lifestyle and biological determinants of health and chronic diseases: the EPIC-Norfolk Prospective population study

随着人口老龄化，一个重大挑战是我们如何保持良好的健康，预防疾病和残疾。EPIC-NOFLOCK(欧洲诺福克癌症前瞻性调查)是一项针对25,000名居住在东安格利亚的40-79岁男性和女性的研究，他们在1993-1997年间提供了关于他们的健康和生活方式的详细信息，特别是饮食和体力活动，并自那以后进行了跟踪，以检查随着年龄的增长哪些因素可以预测健康。这项研究旨在更好地了解如何预防和治疗许多与老龄化有关的慢性疾病，如心脏病和中风、癌症、关节炎、糖尿病、呼吸系统疾病和导致骨折的骨质疏松症，以及如何在晚年保持最佳健康。对血液中新生物标志物的测量，包括基因图谱，也使我们能够更好地了解疾病的过程和进展，这可能有助于我们找到更好的治疗方法。我们继续跟踪这项研究的参与者，并在下一阶段评估身体和精神功能，以检查我们如何随着年龄的增长影响这些功能的变化。

As the population ages, a major challenge is how we can maintain good health and prevent disease and disability. EPIC-Norfolk(European Prospective Investigation into Cancer in Norfolk) is a study of 25,000 men and women aged 40-79 years living in East Anglia who contributed detailed information on their health and lifestyle, in particular, diet and physical activity in 1993-1997 and who have since been followed up to examine what factors predict health as we age. This study aims to understand better how to prevent and treat many of the chronic diseases associated with ageing such as heart disease and stroke, cancer, arthritis, diabetes, respiratory disease and osteoporosis leading to fractures as well as how to maintain optimal health in later life. Measurements of new biologic markers in blood, including genetic profile, are also enabling us to understand better disease processes and progression, which may help us identify better treatments. We continuing to follow up the participants in this study and in the next phase, assess physical and mental function to examine how we can influence how these change as we age.