MRC Centre for Medical Mycology

MRC 医学真菌学中心

基本信息

  • 批准号:
    MR/N006364/1
  • 负责人:
  • 金额:
    $ 218.12万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2016
  • 资助国家:
    英国
  • 起止时间:
    2016 至 无数据
  • 项目状态:
    已结题

项目摘要

The major contribution of fungi to the global burden of disease is not widely appreciated, despite the fact that fungi infect billions of people annually. While most infections are non-life threatening superficial infections, such as athlete's foot, millions of people contract invasive fungal diseases resulting in global mortality figures that rival those of tuberculosis or malaria. Despite their huge burden and high rates of death, fungal infections remain understudied compared with other infectious diseases and there is a pressing need for more research in this field. Experts in the field, including Aberdeen scientists, have identified three priorities that require urgent attention: (i) to improve our ability to detect fungal infections, (ii) to generate better antifungal drugs, and (iii) to enhance the understanding of fungal immunity and its exploitation to fight these diseases. The limited progress in tackling these challenges is due, in large part, to a lack of basic and clinical scientists working in this field in the UK and worldwide.The UK has a small but highly active community of scientists working on fungal diseases (medical mycologists), with the largest group based at The University of Aberdeen (the Aberdeen Fungal Group, AFG). The AFG, which consists of 11 independent research teams, totalling around eighty individuals, is internationally recognised as a leading group in this field. We aim to achieve maximal synergistic potential within the diverse expertise of the AFG by establishing a world-leading MRC Centre of excellence for research and training in Medical Mycology (MCMM). The MCMM will focus on performing cutting-edge interdisciplinary research and on training the next generation of scientists to increase research capacity in this neglected field in the UK. Establishing the MCMM will facilitate full integration of the complementary areas of expertise into six exciting research themes that address the key priorities of this field. Moreover, creation of the MCMM will lead to the recruitment of two academics whose expertise will add significant complementary value to the current group, and enable expansion of our research capacity into important new areas. One post will be in Bioinformatics, which will study and help process our massive biological datasets. This post will empower new technologies that will allow us to gain important insights into the mechanisms of fungal disease. The second post will be in immunology which, in addition to delivering cutting-edge science, will help promote the translation of our scientific discoveries into new diagnostic, preventative and therapeutic applications. The MCMM will also be used as a platform to raise awareness and influence policy regarding the management of fungal diseases within the broader academic community and the general public.A major objective of the MCMM is to increase capacity in medical mycology in the UK by delivering a cohort of 21 basic and clinical researchers through a range of world leading training programmes. This will include a bespoke four-year MRes-PhD programme for 13 students that will provide a broad interdisciplinary training that is not available anywhere else; 3 Early Career Fellowships to promote an early independent research career in medical mycology for outstanding individuals; 5 Fellowships for excellent clinical trainees to provide one year of focussed academic training and research and to establish a foundation for subsequent PhD fellowship applications; and 10 eight-week summer scholarships for fourth-year medical students to stimulate their interest in medical mycology, and to promote links between the MCMM and other centres in this field. The MCMM Fellows, PhD students and clinical trainees will underpin the integration of the AFG, through appointment to jointly-supervised projects within our new research themes, and will significantly advance our understanding of fungal disease.
尽管真菌每年感染数十亿人,但真菌对全球疾病负担的主要贡献并未得到广泛认识。虽然大多数感染是不危及生命的浅表感染,如脚癣,但数百万人感染了侵袭性真菌疾病,导致全球死亡率与结核病或疟疾相媲美。尽管真菌感染负担巨大,死亡率高,但与其他传染病相比,真菌感染的研究仍然不足,迫切需要在这一领域开展更多的研究。该领域的专家,包括阿伯丁的科学家,已经确定了三个需要紧急关注的优先事项:(i)提高我们检测真菌感染的能力,(ii)产生更好的抗真菌药物,(iii)加强对真菌免疫的理解,并利用真菌免疫来对抗这些疾病。在应对这些挑战方面进展有限,在很大程度上是由于在英国和世界范围内缺乏在这一领域工作的基础和临床科学家。英国有一个小型但高度活跃的研究真菌疾病的科学家社区(医学真菌学家),其中最大的群体位于阿伯丁大学(阿伯丁真菌小组,AFG)。AFG由11个独立的研究小组组成,总共约80人,是国际公认的该领域的领导小组。我们的目标是通过建立一个世界领先的医学真菌学(MCMM)研究和培训的MRC卓越中心,在AFG的各种专业知识中实现最大的协同潜力。MCMM将专注于进行尖端的跨学科研究,并培训下一代科学家,以提高英国在这一被忽视领域的研究能力。建立MCMM将有助于将互补的专业领域充分整合到六个令人兴奋的研究主题中,以解决该领域的关键优先事项。此外,MCMM的成立将有助招聘两名学者,他们的专业知识将为现有的团队增加重要的补充价值,并使我们的研究能力扩展到重要的新领域。一个职位将在生物信息学,这将研究和帮助处理我们的大量生物数据集。这篇文章将赋予新技术,使我们能够获得对真菌疾病机制的重要见解。第二个职位将是免疫学,除了提供尖端科学外,还将有助于促进我们的科学发现转化为新的诊断,预防和治疗应用。MCMM还将作为一个平台,在更广泛的学术界和公众中提高对真菌疾病管理的认识并影响政策。MCMM的一个主要目标是通过一系列世界领先的培训方案,培养21名基础和临床研究人员,从而提高英国医学真菌学的能力。这将包括为13名学生定制的四年硕士-博士课程,该课程将提供其他任何地方都无法提供的广泛跨学科培训;3 .早期职业奖学金,鼓励杰出人士在医学真菌学领域开展早期独立研究;5 .为优秀临床实习生提供为期一年的重点学术培训和研究,并为后续的博士奖学金申请奠定基础;为四年级医科学生提供10个为期8周的暑期奖学金,以激发他们对医学真菌学的兴趣,并促进医学真菌学监测中心与该领域其他中心之间的联系。MCMM研究员、博士生和临床实习生将通过在我们新的研究主题中任命共同监督的项目来支持AFG的整合,并将大大促进我们对真菌疾病的理解。

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Macrophage Migration Is Impaired within Candida albicans Biofilms.
The Third International Symposium on Fungal Stress - ISFUS.
  • DOI:
    10.1016/j.funbio.2020.02.007
  • 发表时间:
    2017-11
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Alene Alder-Rangel;A. Idnurm;A. Brand;A. J. Brown;A. Gorbushina;Christina M. Kelliher;C. B. Campos;D. E. Levin;D. Bell-Pedersen;E. Dadachova;F. Bauer;G. Gadd;G. Braus;G. U. Braga;G. Brancini;G. Walker;Irina S Druzhinina;I. Pócsi;J. Dijksterhuis;J. Aguirre;J. E. Hallsworth;J. Schumacher;K. H. Wong;L. Selbmann;L. Corrochano;M. Kupiec;M. Momany;M. Molin;N. Requena;O. Yarden;Radames J. B. Cordero;R. Fischer;R. Pascon;R. Mancinelli;T. Emri;T. O. Basso;D. Rangel
  • 通讯作者:
    Alene Alder-Rangel;A. Idnurm;A. Brand;A. J. Brown;A. Gorbushina;Christina M. Kelliher;C. B. Campos;D. E. Levin;D. Bell-Pedersen;E. Dadachova;F. Bauer;G. Gadd;G. Braus;G. U. Braga;G. Brancini;G. Walker;Irina S Druzhinina;I. Pócsi;J. Dijksterhuis;J. Aguirre;J. E. Hallsworth;J. Schumacher;K. H. Wong;L. Selbmann;L. Corrochano;M. Kupiec;M. Momany;M. Molin;N. Requena;O. Yarden;Radames J. B. Cordero;R. Fischer;R. Pascon;R. Mancinelli;T. Emri;T. O. Basso;D. Rangel
Cryptococcal meningitis after ART: Need for proper baseline evaluation in the era of 'Test & Treat'.
ART 后的隐球菌性脑膜炎:在“测试”时代需要进行适当的基线评估
  • DOI:
    10.1016/j.mmcr.2019.04.003
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Akase IE
  • 通讯作者:
    Akase IE
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Gordon Brown其他文献

The Impact of Varying Resolution and Motion Realism of Avatars in Augmented Reality-Supported, Virtually Co-located Sales Consultations
虚拟人物的不同分辨率和运动真实感对增强现实支持的虚拟同地销售咨询的影响
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Gordon Brown;Julien Hust;S. Büttner;Michael Prilla
  • 通讯作者:
    Michael Prilla
P 0796 r 1 : Supporting Heterogeneous & Distributed Computing Through Affinity
P 0796 r 1:支持异构
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Gordon Brown;Ruyman Reyes;Michael Wong;H. C. Edwards;Thomas Rodgers;M. Hoemmen;Patrice Roy;Carl Cook;Jeff Hammond
  • 通讯作者:
    Jeff Hammond
Developing a Theory-Informed Interactive Animation to Increase Physical Activity among Young People with Asthma
开发基于理论的交互式动画以增加患有哮喘的年轻人的身体活动
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. Murray;B. Williams;G. Hoskins;J. McGhee;D. Gauld;Gordon Brown
  • 通讯作者:
    Gordon Brown
Evaluating Pointing Modes and Frames of Reference for Remotely Supporting an Augmented Reality User in a Collaborative (Virtual) Environment: Evaluation within the Scope of a Remote Consultation Session
评估协作(虚拟)环境中远程支持增强现实用户的指向模式和参考系:远程咨询会话范围内的评估
Renal mass imaging modalities: does body mass index (BMI) matter?
肾脏质量成像方式:体重指数 (BMI) 重要吗?
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Young Son;Mark E. Quiring;Raeann M. Dalton;Brian Thomas;Noah Davidson;Dayna Devincentz;Collin Payne;Sahil H Parikh;B. Fink;Thomas Mueller;Gordon Brown
  • 通讯作者:
    Gordon Brown

Gordon Brown的其他文献

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{{ truncateString('Gordon Brown', 18)}}的其他基金

Dectin-1-mediated suppression of protective anti-mycobacterial immunity
Dectin-1介导的保护性抗分枝杆菌免疫抑制
  • 批准号:
    MR/W025779/1
  • 财政年份:
    2022
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Research Grant
Tackling Emerging Co-Infections
应对新出现的合并感染
  • 批准号:
    MC_PC_21021
  • 财政年份:
    2022
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Intramural
Medical Research Council Centre for Medical Mycology
医学研究委员会医学真菌学中心
  • 批准号:
    MR/V033417/1
  • 财政年份:
    2021
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Research Grant
MRC Centre for Medical Mycology
MRC 医学真菌学中心
  • 批准号:
    MR/N006364/2
  • 财政年份:
    2019
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Research Grant
Characterisation of the C-type lectin receptor CLECSF8 (CLEC4D)
C 型凝集素受体 CLECSF8 (CLEC4D) 的表征
  • 批准号:
    MR/J004820/1
  • 财政年份:
    2012
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Research Grant
RUI: Low Frequency Microwave Spectroscopy of van der Waals Complexes
RUI:范德华配合物的低频微波光谱
  • 批准号:
    1213560
  • 财政年份:
    2012
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Standard Grant
The rank principle in social and cognitive comparison
社会和认知比较中的等级原则
  • 批准号:
    ES/H029249/1
  • 财政年份:
    2010
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Research Grant
Acquisition of an Advanced Detector for Synchrotron-Based X-Ray Absorption Spectroscopy in Earth Sciences
采购用于地球科学中基于同步加速器的 X 射线吸收光谱的先进探测器
  • 批准号:
    0841409
  • 财政年份:
    2010
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Interagency Agreement
EMSI: Chemical and Biological Interactions at Environmental Interfaces
EMSI:环境界面的化学和生物相互作用
  • 批准号:
    0431425
  • 财政年份:
    2004
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Continuing Grant
Chemical and Microbial Interactions at Environmental Interfaces
环境界面的化学和微生物相互作用
  • 批准号:
    0089215
  • 财政年份:
    2000
  • 资助金额:
    $ 218.12万
  • 项目类别:
    Continuing Grant

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