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MNEMONIC PROPERTIES OF THE PREFRONTAL CORTEX

前额叶皮层的记忆特性

基本信息

批准号：
2890007
负责人：
MICHAEL E RAGOZZINO
金额：
$ 0.35万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/2890007
关键词：
acetylcholine behavioral /social science research tag frontal lobe /cortex laboratory rat memory neural information processing neurochemistry psychomotor function space perception visual perception

项目摘要

There is accumulating evidence that the prefrontal cortex is involved in working memory in several mammalian species. Prefrontal cortex damage leads to a variety of working memory deficits in humans, as well as rodents. These results suggest that the prefrontal cortex may be involved in working memory for different attributes, i.e. space, affect, motor responses. Recent evidence suggest that the type of working memory deficit that results following prefrontal cortex damaged may be related to the lesion site. Understanding whether specific prefrontal cortex subregions mediate different types of information within a working memory context, will lend important insight into the biology of memory. To build a more comprehensive view of the neural processes that underlie memory within prefrontal cortex subregions, also calls for an examination of the neurotransmitter systems that may play a critical role. The present proposal examines the neural processes in the prefrontal cortex important for working memory of different attributes. The first set of experiments investigates whether there are dissociations between the anterior cingulate, prelimbic/infralimbic and agranular insular in mediating working memory for spatial locations, visual objects, affect and motor responses. Based on previous studies and preliminary data, it is predicted that the anterior cingulate mediates working memory for motor responses, the prelimbic/infralimbic mediates working memory for space and objects and the agranular insular mediates working memory for affect. The second set of experiments assesses whether acetylcholine within prefrontal cortex subregions modulates working memory for different attributes. The hypothesis is that the cholinergic system is important in all prefrontal subregions for processing working memory for specific attributes. Overall, these experiments will provide a better understanding of the mnemonic functions mediated by prefrontal cortex subregions and the neurochemical modulation of these functions. Thus, the studies may increase our knowledge about the neurobiology of memory and may ultimately lead to effective treatments for cognitive dysfunctions.

越来越多的证据表明，前额叶皮层参与了几种哺乳动物的工作记忆。前额叶大脑皮层损伤会导致多种工作记忆缺陷，人类和啮齿类动物这些结果表明前额叶皮层可能参与不同的工作记忆，属性，即空间，情感，运动反应。最近的证据这表明工作记忆缺失的类型以下前额叶皮层受损可能与病变有关绝佳的价钱了解特定的前额叶皮层分区在工作记忆中传递不同类型的信息背景下，将提供重要的洞察生物学的记忆。到建立一个更全面的神经过程的视图，在前额叶皮层分区内的记忆基础，也要求对神经递质系统的检查，关键作用。目前的建议审查的神经过程前额叶皮层对不同的工作记忆很重要美德.先知-愿第一组实验调查是否有是前扣带之间的分离，边缘前/边缘下和无颗粒岛叶介导工作空间位置记忆、视觉对象记忆、情感记忆和运动记忆应答根据以前的研究和初步数据，预测前扣带回介导的工作记忆，运动反应，前边缘/边缘下介导工作记忆和无颗粒岛状介导的工作记忆的影响。第二组实验评估是否前额叶皮层亚区内的乙酰胆碱调节工作不同属性的内存。假设是，胆碱能系统在所有前额叶亚区都很重要，为特定的属性处理工作记忆。总的来说，这些实验将提供更好的理解记忆功能介导的前额叶皮层分区和这些功能的神经化学调节。因此，研究可能增加我们对记忆的神经生物学的了解，最终导致认知功能障碍的有效治疗。