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STRIATAL CIRCUITRY AND BEHAVIORAL FLEXIBILITY

纹状体回路和行为灵活性

基本信息

批准号：
6166891
负责人：
MICHAEL E RAGOZZINO
金额：
$ 3.46万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-04-25 至 2002-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6166891
关键词：
behavioral /social science research tag corpus striatum cues discrimination learning environmental adaptation laboratory rat neuroanatomy problem solving psychological adaptation sensory discrimination visual perception

项目摘要

The thriving and survival of humans, as well as other species fundamentally depends on the ability to rapidly adapt to changing environmental contingencies. The long-term objective is to understand the brain circuitry that facilitates the learning of new rules with exposure to changing conditions. Huntington's and Parkinson's disease are marked by cellular alterations in the striatum and patients with these diseases exhibit deficits in cognitive flexibility. These findings suggest that the striatum is one brain area that may play a central role in cognitive flexibility. However, the striatum is made up of different subregions possibly subserving different cognitive and behavioral functions. Understanding whether particular striatal subregions facilitate the learning and flexible use of behavior-guiding rules, e.g. switiching strategies, will lend important insight into the neurobiology of learning and behavior flexibility. Ultimately, information obtained on the neurocircuitry underlying behavioral flexibility may enable the development of effective treatments for alleviating the cognitive symptomology observed in patients with Huntington's and Parkinson's disease. The present proposal examines whether the dorsomedial striatum in rats is involved in different forms of behavioral flexibility. In a related group of experiments, the effect of dorsomedial striatal inactivation on the learning and reversal of visual cue and turn discrimination rules are evaluated. Specific to behavioral flexibility, these experiments will examine whether dorsomedial striatal inactivation impairs learning when rats have to shift within a dimension (intra-dimensional shift), e.g. shift from a left turn rule to a right turn rule, or between a dimension (extra-dimension shift), e.g. shift from a visual cue rule to a turn rule. Overall, the findings from the proposed studies can increase the present knowledge about the brain circuitry underlying learning and behavioral flexibility.

人类以及其他物种的繁荣和生存从根本上取决于迅速适应变化的环境突发事件的能力。长期目标是了解在不断变化的条件下促进新规则学习的大脑回路。亨廷顿氏症和帕金森氏症的特征是纹状体的细胞改变，这些疾病的患者表现出认知灵活性的缺陷。这些发现表明，纹状体是大脑中可能在认知灵活性中发挥核心作用的一个区域。然而，纹状体由不同的亚区组成，可能服务于不同的认知和行为功能。了解特定纹状体亚区是否有助于学习和灵活使用行为指导规则，例如切换策略，将为学习和行为灵活性的神经生物学提供重要的见解。最终，获得的关于行为灵活性背后的神经回路的信息可能有助于开发有效的治疗方法，以减轻亨廷顿氏病和帕金森病患者观察到的认知症状。本研究探讨了大鼠的背内侧纹状体是否参与不同形式的行为灵活性。在一组相关的实验中，我们评估了背内侧纹状体失活对视觉线索和转身辨别规则的学习和逆转的影响。具体到行为灵活性，这些实验将检查背内侧纹状体失活是否会损害大鼠在一个维度内（内维度转移），例如从左转规则转移到右转规则，或在一个维度之间（外维度转移），例如从视觉提示规则转移到转弯规则。总的来说，拟议研究的发现可以增加目前对学习和行为灵活性背后的大脑回路的了解。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Differential effects of M1 muscarinic receptor blockade and nicotinic receptor blockade in the dorsomedial striatum on response reversal learning.

背内侧纹状体 M1 毒蕈碱受体阻断和烟碱受体阻断对反应逆转学习的不同影响。

DOI：
10.1016/j.bbr.2004.02.011
发表时间：
2004
期刊：
Behavioural brain research
影响因子：
2.7
作者：
Tzavos,Arianna;Jih,Jane;Ragozzino,MichaelE
通讯作者：
Ragozzino,MichaelE

Dynamic changes in acetylcholine output in the medial striatum during place reversal learning.

DOI：
10.1101/lm.65404
发表时间：
2004
期刊：
Learning & memory
影响因子：
2
作者：
M. Ragozzino;D. Choi
通讯作者：
M. Ragozzino;D. Choi

Acetylcholine activity in selective striatal regions supports behavioral flexibility.

DOI：
10.1016/j.nlm.2008.09.008
发表时间：
2009-01
期刊：
NEUROBIOLOGY OF LEARNING AND MEMORY
影响因子：
2.7
作者：
Ragozzino, Michael E.;Mohler, Eric G.;Prior, Margaret;Palencia, Carlos A.;Roman, Suzanne
通讯作者：
Roman, Suzanne

The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility.

前边缘-下边缘区域多巴胺 D(1) 受体阻断对行为灵活性的影响。