MOTION CORRECTED TREADMILL NUCLEAR ANGIOGRAPHY

运动校正跑步机核血管造影

• 批准号: 2797672
• 负责人: JEFFREY L LACY
• 金额: $ 10万
• 依托单位: PROPORTIONAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-15 至 1999-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2797672
• 关键词: angiography; bioimaging /biomedical imaging; biomedical equipment development; chordate locomotion; computer system design /evaluation; electronic recording system; exercise; human subject; magnetic recording system; performance; phantom model; scintillation cameras

One of the most pressing needs in clinical cardiology today is a convenient, reliable,and low-cost front-line screening procedure for risk stratification of patients presenting with angina pectoris and/or other cardiac symptoms. Exercise first-pass radionuclide angiography (FPRNA) provides valuable prognostic information and serves as an ideal candidate for such a widespread screening test. Unfortunately, treadmill exercise, the highly preferred method of achieving peak stress, results in significant patient motion during image acquisition. Current methods for correction of this motion are complicated. present potential safety issues, and have technical limitations. These drawbacks combined with the high cost of current scintillation cameras have prevented broad application of this technique. which could be of very high clinical significance. In this application, we propose to develop a motion corrected treadmill nuclear angiography system through use of state-of-the-art motion tracking technology developed in the computer animation industry. The dedicated system, including treadmill mounting, will consist of the low-cost Multiwire Gamma Camera integrated with a sensor worn by the patient and a fixed position transmitter. Phantom studies evaluating the accuracy of motion correction will be conducted. Following these simulations, a prototype system will be constructed and evaluated in 10 human volunteer subjects at the Cornell Medical Center in order to establish the feasibility of such a system. PROPOSED COMMERCIAL APPLICATIONS: A motion correction treadmill angiography system as described could effectively function as a front-line screening test for risk stratification of incoming patients. Considering the high incidence of heart disease in addition to the multitude of symptomatic but disease-free patients, such studies would be performed in a large volume of patients. There would be a high demand for the proposed system, which could be provided at relatively low cost, at large hospitals as well as smaller clinics.

当今临床心脏病学最迫切的需求之一是方便、可靠和低成本的一线筛查程序，用于对出现心绞痛和/或其他心脏症状的患者进行风险分层。运动首过放射性核素血管造影（FPRNA）提供了有价值的预后信息，并作为一个理想的候选人，这样一个广泛的筛选测试。不幸的是，跑步机运动，高度优选的方法，实现峰值应力，导致显着的患者运动在图像采集。目前用于校正这种运动的方法是复杂的。存在潜在的安全问题并具有技术限制。这些缺点与当前闪烁相机的高成本相结合，阻碍了该技术的广泛应用。这可能具有非常高的临床意义。在本申请中，我们建议通过使用计算机动画行业中开发的最先进的运动跟踪技术来开发运动校正跑步机核血管造影系统。专用系统（包括跑步机安装）将由低成本多线伽马照相机组成，该照相机集成有患者佩戴的传感器和固定位置发射器。将进行体模研究，评价运动校正的准确性。在这些模拟之后，将在康奈尔医学中心的10名人类志愿者中构建和评估原型系统，以确定这种系统的可行性。拟议的商业应用：所描述的运动校正跑步机血管造影系统可以有效地用作对进入的患者进行风险分层的一线筛选测试。考虑到心脏病的高发病率以及大量有症状但无疾病的患者，此类研究将在大量患者中进行。建议的系统会有很大的需求，因为它可以以相对较低的成本在大型医院和较小的诊所提供。