NON RADIOACTIVE METHOD TO MEASURE ORGAN BLOOD FLOW
测量器官血流量的非放射性方法
基本信息
- 批准号:2790956
- 负责人:
- 金额:$ 9.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-02-15 至 2000-02-29
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (Adapted from applicant's abstract): The specific aim of the
proposed study is to validate a new method of measuring regional organ blood
flow using non-radioactive, stable-labeled microspheres assayed by neutron
activation (NA) analysis. The proposal is based on the hypothesis that
stable-labeled research products introduced into a biological matrix can be
accurately and rapidly assayed using NA. This technology will provide a
cost-effective method for reducing the production of low-level radioactive
waste generated from biomedical research. The long-term goal is to develop
additional research products based on the NA technology, which could be used in
applications where current non-radioactive methods are labor-intensive and less
effective. Phase I of the proposed project is an in-house alpha test which will
directly compare stable-labeled microspheres to a co-injection of radiolabeled
microspheres in an in vivo rabbit model of coronary occlusion and reperfusion.
Statistical analysis will be used to assess agreement between the two methods,
thereby supporting the working hypothesis and demonstrating feasibility. Phase
I will also provide important design parameters for an automated activation and
counting system to be constructed during Phase II. This automated system will
be able to assay the large numbers of samples necessary for commercial
operation.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
描述:(改编自申请人的摘要):
拟议的研究是验证一种测量局部器官血液的新方法
使用中子测定的非放射性、稳定标记的微球的流动
活化(NA)分析。该建议基于以下假设:
引入生物基质中的稳定标记的研究产品可以
使用NA准确快速测定。这项技术将提供一个
降低低放射性核素产生的成本效益高的方法
生物医学研究产生的废物。长期目标是发展
基于NA技术的其他研究产品,可用于
目前的非放射性方法是劳动密集型的,
有效拟议项目的第一阶段是内部阿尔法测试,
直接比较稳定标记的微球与放射性标记的
在冠状动脉闭塞和再灌注的体内兔模型中的微球。
将使用统计分析评估两种方法之间的一致性,
从而支持工作假设并证明可行性。相
我还将提供自动激活的重要设计参数,
在第二阶段建设的计数系统。该自动化系统将
能够分析商业所需的大量样品,
操作
拟议商业应用:不可用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHRISTOPHER P REINHARDT其他文献
CHRISTOPHER P REINHARDT的其他文献
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{{ truncateString('CHRISTOPHER P REINHARDT', 18)}}的其他基金
Evaluate a novel product to simultaneously remove dead cells, cellular membranes,
评估一种同时去除死细胞、细胞膜、
- 批准号:
8310392 - 财政年份:2012
- 资助金额:
$ 9.9万 - 项目类别:
Novel method to measure glomerular filtration rate
测量肾小球滤过率的新方法
- 批准号:
6926210 - 财政年份:2004
- 资助金额:
$ 9.9万 - 项目类别:
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