Optimizing strategies to diagnose and control intestinal Schistosomiasis in low and moderate endemicity areas of Brazil

优化巴西低度和中度流行地区肠道血吸虫病的诊断和控制策略

• 批准号: MR/N017722/1
• 负责人: Anna Phillips
• 金额: $ 11.54万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN017722%2F1
• 关键词: Optimizing; strategies; diagnose; control; intestinal

Over 200 million people suffer with the disease Schistosomiasis which is caused by the presence in the human blood vessels of trematode worms of the genus Schistosoma. This leads to long term disability and can be fatal. Therefore, intestinal and urinary schistosomiasis are considered serious public health problems in vast regions of Africa, Asia and Latin America. The current mainstream diagnostic method for intestinal schistosomiasis is the detection of eggs in stool by Kato-Katz. This method, however, is limited costly, time-consuming, and may be particularly unreliable where there is low levels of infection, as would be expected after several rounds of treatment or in regions where transmission is low. In order to overcome some of the pitfalls of this diagnostic method, there has been interest in developing new and more sensitive tests for the diagnosis of schistosomiasis. Antigen detection in urine (CCA) has been documented to be a sensitive and specific alternative to Kato-Katz in several moderate and high endemnicity settings. Data comparing the performance of stool microscopy (Kato-Katz) and a urine dipstick (CCA) in low Schistosomiasis prevalence settings, however, is currently lacking. In this context, the aim of this project is to compare the performance of CCA with Kato-Katz in the low endemic area of Minas Gerais State, and in a moderate endemic area of Sergipe State Brazil. Furthermore, the study aims to enhance knowledge of the spatial distribution of schistosomiasis in Brazil that will assist planning of the preventive chemotherapy strategy for the national schistosomiasis control programme.

超过2亿人患有血吸虫病，这是由血吸虫属蠕虫在人体血管中的存在引起的。这会导致长期残疾，并可能致命。因此，在非洲、亚洲和拉丁美洲的广大地区，肠道和泌尿系统血吸虫病被认为是严重的公共卫生问题。目前肠血吸虫病的主流诊断方法是Kato-Katz检测粪便中的虫卵。然而，这种方法是有限的，昂贵的，耗时的，并且在感染水平低的情况下可能特别不可靠，正如在几轮治疗后或在传播率低的地区所预期的那样。为了克服这种诊断方法的一些缺陷，人们一直有兴趣开发新的和更敏感的血吸虫病诊断测试。尿液中的抗原检测（CCA）已被证明是一个敏感和具体的替代加藤Katz在几个中度和高度流行的设置。然而，目前缺乏比较粪便显微镜检查（Kato-Katz）和尿试纸（CCA）在血吸虫病低流行环境中的性能的数据。在这种情况下，本项目的目的是比较的性能CCA与卡托-卡茨在低流行地区的米纳斯吉拉斯州，并在中度流行地区的塞尔吉佩州巴西。此外，该研究旨在提高巴西血吸虫病的空间分布的知识，这将有助于规划国家血吸虫病控制方案的预防性化疗战略。

项目成果

Discrepancy between batches and impact on the sensitivity of point-of-care circulating cathodic antigen tests for Schistosoma mansoni infection

• DOI: 10.1016/j.actatropica.2019.105049
• 发表时间: 2019-09-01
• 期刊: ACTA TROPICA
• 影响因子: 2.7
• 作者: Viana, Agostinho Goncalves;Gazzinelli-Guimaraes, Pedro Henrique;Fujiwara, Ricardo Toshio
• 通讯作者: Fujiwara, Ricardo Toshio