WHITE COAT HYPERTENSION--PSYCHOBEHAVIORAL MECHANISMS

这项研究的总体目标是调查心理学 和行为机制可能是造成白色被毛的原因 高血压根据临床观察研究的证据， 以及与大量心理学文献或主要心理学文献的明显相似之处， 重点是压力和经典条件反射探讨 应激和经典条件作用在白色被毛中的可能作用 高血压，我们提出了一个研究计划，结合三个 补充研究：1）纵向相关研究 心理行为变量与白色被毛动物高血压之间的关系; 2） 心血管反应的实验研究 压力和条件反射; 3）两个对照临床研究 基于压力和经典条件作用的实验操作 理论将对三组（n=150/组）受试者（50%女性）进行 招募：a）临床鉴定为具有白色被毛的个体 高血压（WCHT-组），B）临床上被鉴定为患有 中度高血压（EH组），c）被确定为 血压正常（NT组）。具体目标1：研究 白色被毛高血压与心理因素的关系， 来自压力和经典条件反射理论的行为因素。 具体目标3：测试压力和经典之间的因果关系 白色被毛动物高血压的条件性预测因子。拟议研究 将是第一个同时研究压力的贡献 和经典条件反射对白色被毛高血压现象的影响。 更好地了解这些机制可能有助于指导 制定针对这一人群的有效干预措施，包括 具体的心理行为干预。此外，该方案 研究可能有助于澄清有关冲突的文献， 白色被毛高血压的潜在致病后果。

The overall goal of the proposed research is to investigate psychological and behavioral mechanisms that may be responsible for white coat hypertension. Based on the evidence from clinical observation studies, as well as the clear parallels to a vast psychology literature, or primary focus will be on stress and classical conditioning. To explore the possible roles of stress and classical conditioning in white coat hypertension, we propose a program of research that combines three complementary studies: 1) a longitudinal correlational study of relations between psychobehavioral variables and white coat hypertension; 2) an experimental study of cardiovascular responses to laboratory models of stress and conditioning; 3) a controlled clinical study of two experimental manipulations based on stress and classical conditioning theory. Three groups (n=150/group) of subjects (50% women) will be recruited: a) individuals clinically identified as having white coat hypertension (WCHT-Group), b) individuals clinically identified as having moderate established hypertension (EH-Group), c) individuals identified as being normotensive (NT-Group). Specific Aim 1: To investigate the relationships between white coat hypertension and psychological, and behavioral factors derived from stress and classical conditioning theory. Specific Aim 3: To test the causal relations between stress and classical conditioning predictors of white coat hypertension. The proposed research will be the first to concurrently investigate the contributions of stress and classical conditioning to the phenomenon of white coat hypertension. A greater understanding of those mechanisms may help provide guidance for the development of effective interventions with this population, including specific psychobehavioral interventions. Furthermore, the program of research may help to clarify the conflicting literature concerning potential pathogenic consequences of white coat hypertension.