Internatioanl Follow-UP of ABPM and CV Events

摘要 该项目将检查ABP预测心血管疾病发病率的能力，并代表了一个 继续我们在两个相关领域的工作。第一项研究将是对过去23年来我们组进行动态血压监测（ABPM）的患者以及临床压力进行持续随访，以确定不同血压测量对特定心血管疾病事件的相对预测价值。第二项研究将涉及汇集来自美国以外国家的研究者的可比数据，这些研究者已进行了前瞻性ABPM研究并评估了心血管疾病事件，以增加样本量，从而增加检查ABPM对心血管疾病发病率的预测效用的把握度。这项国际合作项目已经汇集了来自4个组的数据，共6，320名受试者，并将增加来自4个组的数据。这些合并数据将包括 在世界各地进行的大部分ABP前瞻性研究。 项目1的具体目标是：1。探讨白色被毛犬高血压（WCHT）与血压正常者和持续性高血压者的心血管预后关系。探讨隐匿性高血压与正常血压及持续性高血压患者的心血管预后关系。探讨血压夜间下降状态和晨峰状态对预后的意义。确定血压变异性的预后意义; 5.确定ABP在非裔美国人中的预后意义; 6.比较ABP在具有不同风险因素特征的人群（日本人vs.欧洲人vs.美国人）中的预后意义;以及7.解决个体数据库中关于ABP和预后的不一致结果。

Abstract This project will examine the ability of ABP to predict cardiovascular morbidity, and represents a continuation of our work in two related areas. The first will be a continued follow-up of patients who have had ambulatory blood pressure monitoring (ABPM) performed by our group during the last 23 years, as well as clinic pressures, to establish the relative predictive value of different measures of BP for specific cardiovascular morbid events. The second will involve pooling comparable data from investigators in countries outside the US who have performed prospective ABPM studies and assessed cardiovascular morbid events, to increase the sample size, and thus increase the power to examine the predictive utility of ABPM for cardiovascular morbidity. This international collaborative project has already pooled data from 4 groups, with a total of 6,320 subjects, and will add data from 4 more. These combined data will include the bulk of the prospective studies on ABP performed throughout the world. The specific aims of Project 1 are: 1. To determine the cardiovascular prognosis of white coat hypertension (WCHT) in relation to normotension and sustained hypertension ; 2. To determine the cardiovascular prognosis of masked hypertension in relation to normotension and sustained hypertension; 3. To determine the prognostic significance of nocturnal dipping status and the morning surge of BP; 4. To determine the prognostic significance of blood pressure variability; 5. To determine the prognostic significance of ABP in African-Americans; 6. To compare the prognostic significance of ABP in populations with different risk factor profiles (Japanese vs. Europeans vs. Americans); and 7. To resolve discrepant findings from individual databases concerning ABP and prognosis.