Internatioanl Follow-UP of ABPM and CV Events

ABPM 和 CV 事件的国际跟进

• 批准号: 6816455
• 负责人: Thomas G Pickering
• 金额: $ 21.6万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6816455
• 关键词: African American; behavioral /social science research tag; behavioral medicine; blood pressure; cardiovascular disorder epidemiology; circadian rhythms; clinical research; echocardiography; environment associated hypertension; family structure /dynamics; gender difference; heart disorder; human subject; hypertension; kidney disorder; longitudinal human study; occupational stressor; polysomnography; psychological stressor; socioeconomics; socioenvironment; stress; urinalysis

Abstract This project will examine the ability of ABP to predict cardiovascular morbidity, and represents a continuation of our work in two related areas. The first will be a continued follow-up of patients who have had ambulatory blood pressure monitoring (ABPM) performed by our group during the last 23 years, as well as clinic pressures, to establish the relative predictive value of different measures of BP for specific cardiovascular morbid events. The second will involve pooling comparable data from investigators in countries outside the US who have performed prospective ABPM studies and assessed cardiovascular morbid events, to increase the sample size, and thus increase the power to examine the predictive utility of ABPM for cardiovascular morbidity. This international collaborative project has already pooled data from 4 groups, with a total of 6,320 subjects, and will add data from 4 more. These combined data will include the bulk of the prospective studies on ABP performed throughout the world. The specific aims of Project 1 are: 1. To determine the cardiovascular prognosis of white coat hypertension (WCHT) in relation to normotension and sustained hypertension ; 2. To determine the cardiovascular prognosis of masked hypertension in relation to normotension and sustained hypertension; 3. To determine the prognostic significance of nocturnal dipping status and the morning surge of BP; 4. To determine the prognostic significance of blood pressure variability; 5. To determine the prognostic significance of ABP in African-Americans; 6. To compare the prognostic significance of ABP in populations with different risk factor profiles (Japanese vs. Europeans vs. Americans); and 7. To resolve discrepant findings from individual databases concerning ABP and prognosis.

摘要 这个项目将检验ABP预测心血管发病率的能力，并代表了一个 继续我们在两个相关领域的工作。第一个是对我们小组在过去23年中进行动态血压监测(ABPM)的患者的持续随访，以及临床压力，以建立不同血压测量方法对特定心血管疾病事件的相对预测价值。第二项研究将汇集来自美国以外国家的研究人员的可比数据，这些研究人员已经进行了前瞻性的ABPM研究并评估了心血管疾病事件，以增加样本量，从而增加检查ABPM对心血管发病率的预测效用的能力。这个国际合作项目已经汇集了来自4个小组的数据，总共有6,320个主题，并将增加来自另外4个小组的数据。这些合并的数据将包括 关于ABP的大部分前瞻性研究在世界各地进行。 项目1的具体目标是：1.确定与正常血压和持续性高血压有关的白大衣高血压(WCHT)的心血管预后；2.确定与正常血压和持续性高血压有关的隐性高血压的心血管预后；3.确定夜间低血压状态和晨峰血压的预后意义；4.确定血压变异性的预后意义；5.确定ABP在非裔美国人中的预后意义；6.比较ABP在不同危险因素人群(日本人、欧洲人和美国人)中的预后意义；7.解决个人数据库中关于ABP和预后的不一致发现。