MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTURE

描述（由申请人提供）：我们已经确定了5个障碍，我们认为这些障碍阻碍了身心（行为）医学对一般医学界的影响。每一个都是我们基础设施提案的主题，并将通过4个核心来解决。第一个主题涉及因果机制：许多与压力、认知和情绪有关的证据都是基于观察性研究。我们建议在干预性试验中更好地测试这些机制，并且相同的介质可能参与不同类型的行为干预。因此，在核心A（机制）中，我们将开发2个测试组合，一个评估行为因素（基于认知适应理论），另一个评估生物因素（基于非稳态负荷的概念），我们将在3个正在进行的行为临床试验中评估其因果关系。第二个主题是心理变量的测量缺乏标准化，这将由核心A中的拟议电池处理，以及核心D（传播）中其他相关评估领域的科克伦审查。第三个主题是健康差距和种族。大多数慢性病的流行和不良后果在少数群体中更为严重，心理社会因素被认为起着主要作用。然而，许多用于评估这些的工具尚未在这些人群中进行充分测试。核心B（少数群体健康监督）将解决这些问题。第四个主题是信息技术（核心C）。患者与研究人员或治疗师之间的沟通对于任何行为医学奋进都至关重要，我们建议开发使用平板电脑和手持计算机进行数据采集的新技术，这将提高数据的质量。此外，行为医学是跨学科的，核心c将促进哥伦比亚社区内外的研究者之间的交流。第五个主题是传播（核心D）-我们相信大多数医疗从业者只是不知道行为医学的现有成就，这个核心将执行和传播行为干预试验和评估工具的科克伦评论。 最终目标是将我们的研究结果提供给3个目标受众：1）哥伦比亚的研究人员网络; 2）行为医学界; 3）一般医学界。

DESCRIPTION (provided by applicant): We have identified 5 barriers, which we believe have impeded the impact of mind-body (behavioral) medicine on the general medical community. Each of these is a theme of our infrastructure proposal, and will be addressed by 4 Cores. The 1st theme concerns causal mechanisms: much of the evidence relating stress, cognitions, and emotions to chronic disease is based on observational studies. We propose that such mechanisms are better tested within interventional trials, and that the same mediators may be involved in different types of behavioral intervention. Accordingly, in Core A (Mechanisms) we will develop 2 test batteries, one evaluating behavioral factors (based on cognitive adaptation theory), and the other biological factors (based on the concept of allostatic load), and we will assess their causal status 3 ongoing behavioral clinical trials. The 2nd theme is lack of standardization of measures of psychological variables, which will be dealt with by the proposed battery in CoreA, and also a Cochrane review of other relevant assessment areas in Core D (Dissemination). The 3rd theme is health disparities and ethnicity. The prevalence and adverse consequences of most chronic diseases are worse in minority populations, and psychosocial factors are thought to play a major role. However, many of the instruments used to evaluate these have not been adequately tested in these populations. Core B (Minority Health Oversight) will address these issues. The 4th theme is information technology (Core C). Communication between patients and investigators or therapists is critical to any behavioral medicine endeavor, and we propose developing new techniques for data acquisition using tablet and hand-held computers, which should improve the quality of the data. In addition, behavioral medicine is interdisciplinary, and Core c will facilitate communications between investigators both within the Columbia community and outside it. The 5th theme is dissemination (Core D) - we believe that most medical practitioners are simply unaware of the existing achievements of behavioral medicine, and this Core will perform and disseminate Cochrane reviews of behavioral intervention trials and assessment instruments. The ultimate goal will be to make our findings available to 3 target audiences: 1) the network of investigators at Columbia; 2) the behavioral medicine community; and 3) the general medical community.