SIGNAL TRANDUCTION IN POLYCYTHEMIA VERA

真性红细胞增多症的信号转导

基本信息

  • 批准号:
    6030835
  • 负责人:
  • 金额:
    $ 30.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-08-01 至 2000-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: The long term objective of our research is to define the mechanisms responsible for polycythemia vera (PV), a clonal disorder of unknown etiology which involves erythroid, myeloid and megakaryocytic progenitor cells. Recent studies in our laboratory have indicated that PV erythroid progenitor cells, in contrast to normal erythroid progenitor cells, are resistant to the apoptosis associated with erythropoietin (EPO) deprivation. We have also identified a novel signal transduction defect in PV platelets involving thrombopoietin (TPO)-mediated protein tyrosine phosphorylation. These observations have important implications with respect to both the pathogenesis of PV and its clinical manifestations. Based on our observations to date, we now plan to examine TPO-mediated PV platelet signal transduction with respect to platelet c-Mpl expression, the interaction of c-Mpl in PV megakaryocytes as compared to PV platelets. To identify the mechanisms for apoptosis-resistance in PV, using a liquid suspension culture system capable of expanding the population of both normal and PV peripheral blood erythroid progenitor cells, we plan to examine the mechanisms involved in the expression and regulation of Bcl-2 family genes and p53 in the presence and absence of EPO, and using neutrophils as a surrogate model for myeloid cells, to determine whether the apoptosis-resistance associated with growth factor deprivation and its mechanism are global characteristics of PV hematopoiesis.
描述:我们研究的长期目标是定义

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A novel thrombopoietin signaling defect in polycythemia vera platelets.
真性红细胞增多症血小板中一种新型血小板生成素信号缺陷。
  • DOI:
    10.1002/stem.5530160721
  • 发表时间:
    1998
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Moliterno,AR;Siebel,KE;Sun,AY;Hankins,WD;Spivak,JL
  • 通讯作者:
    Spivak,JL
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Jerry L Spivak其他文献

Jerry L Spivak的其他文献

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{{ truncateString('Jerry L Spivak', 18)}}的其他基金

Animal Models of P. Vera
维拉动物模型
  • 批准号:
    7502150
  • 财政年份:
    2007
  • 资助金额:
    $ 30.95万
  • 项目类别:
Animal Models of Polycythemia Vera
真性红细胞增多症的动物模型
  • 批准号:
    8722848
  • 财政年份:
    2006
  • 资助金额:
    $ 30.95万
  • 项目类别:
Animal Models of Polycythemia Vera
真性红细胞增多症的动物模型
  • 批准号:
    8377872
  • 财政年份:
    2006
  • 资助金额:
    $ 30.95万
  • 项目类别:
Animal Models of Polycythemia Vera
真性红细胞增多症的动物模型
  • 批准号:
    8925001
  • 财政年份:
    2006
  • 资助金额:
    $ 30.95万
  • 项目类别:
Animal Models of Polycythemia Vera
真性红细胞增多症的动物模型
  • 批准号:
    8064161
  • 财政年份:
    2006
  • 资助金额:
    $ 30.95万
  • 项目类别:
Animal Models of Polycythemia Vera
真性红细胞增多症的动物模型
  • 批准号:
    8533751
  • 财政年份:
    2006
  • 资助金额:
    $ 30.95万
  • 项目类别:
Animal Models of P. Vera
维拉动物模型
  • 批准号:
    7113541
  • 财政年份:
    2005
  • 资助金额:
    $ 30.95万
  • 项目类别:
Polycythemia Vera Monograph
真性红细胞增多症专着
  • 批准号:
    6474817
  • 财政年份:
    2001
  • 资助金额:
    $ 30.95万
  • 项目类别:
SIGNAL TRANDUCTION IN POLYCYTHEMIA VERA
真性红细胞增多症的信号转导
  • 批准号:
    2379032
  • 财政年份:
    1997
  • 资助金额:
    $ 30.95万
  • 项目类别:
SIGNAL TRANDUCTION IN POLYCYTHEMIA VERA
真性红细胞增多症的信号转导
  • 批准号:
    2735387
  • 财政年份:
    1997
  • 资助金额:
    $ 30.95万
  • 项目类别:

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ROLE OF CELL ADHESION IN BIOLOGICAL SIGNAL TRANSDUCTION
细胞粘附在生物信号转导中的作用
  • 批准号:
    6238317
  • 财政年份:
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  • 资助金额:
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  • 项目类别:
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