EVOBIOTIC: Capturing the natural antibiotic'ome: Developing Nature's EVOlved AntiBIOTIC

EVOBIOTIC：捕获天然抗生素组：开发 Natures EVOlved AntiBIOTIC

• 批准号: MR/N501839/1
• 负责人: Gregory Challis
• 金额: $ 34.89万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN501839%2F1
• 关键词: EVOBIOTIC; Capturing; natural; antibiotic; ome

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，所有资助研究的摘要都不能在GTR中找到。这通常是因为在提交提案时并不需要摘要，但可能是因为它包含了个人详细信息等敏感信息。

项目成果

Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.

• DOI: 10.1002/anie.202009007
• 发表时间: 2020-12-14
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Nakou IT;Jenner M;Dashti Y;Romero-Canelón I;Masschelein J;Mahenthiralingam E;Challis GL
• 通讯作者: Challis GL

Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates*.

• DOI: 10.1002/anie.202009110
• 发表时间: 2020-11-23
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Dashti Y;Nakou IT;Mullins AJ;Webster G;Jian X;Mahenthiralingam E;Challis GL
• 通讯作者: Challis GL

Discovery and biosynthesis of persiathiacins: Unusual polyglycosylated thiopeptides active against multi-drug resistant tuberculosis

• DOI: 10.1101/2021.10.24.465558
• 发表时间: 2021-10
• 期刊: bioRxiv
• 作者: Y. Dashti;F. Mohammadipanah;M. Belousoff;Anthony Vocat;Daniel Zabala;C. Fage;I. Romero‐Canelón;B. Bun

Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism

基因组学驱动的从剑兰伯克霍尔德氏菌中发现新型戊二酰亚胺抗生素揭示了不寻常的聚酮合酶链释放机制

• DOI: 10.1002/ange.202009007
• 发表时间: 2020
• 期刊: Angewandte Chemie
• 作者: Nakou I