Exploitation of Burkholderia bacteria as novel antibiotic producers using a genome mining approach

使用基因组挖掘方法将伯克霍尔德氏菌开发为新型抗生素生产者

• 批准号: BB/L023342/1
• 负责人: Gregory Challis
• 金额: $ 45.2万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL023342%2F1
• 关键词: Exploitation; Burkholderia; bacteria; novel; antibiotic

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Diene incorporation by a dehydratase domain variant in modular polyketide synthases.

• DOI: 10.1038/s41589-022-01127-y
• 发表时间: 2022-12
• 期刊: Nature chemical biology
• 影响因子: 14.8
• 作者: Hobson C;Jenner M;Jian X;Griffiths D;Roberts DM;Rey-Carrizo M;Challis GL
• 通讯作者: Challis GL

Kill and cure: genomic phylogeny and bioactivity of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles.

• DOI: 10.1099/mgen.0.000515
• 发表时间: 2021-01
• 期刊: Microbial genomics
• 影响因子: 3.9
• 作者: Jones C;Webster G;Mullins AJ;Jenner M;Bull MJ;Dashti Y;Spilker T;Parkhill J;Connor TR;LiPuma JJ;Challis GL;Mahenthiralingam E
• 通讯作者: Mahenthiralingam E

Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates*.

• DOI: 10.1002/anie.202009110
• 发表时间: 2020-11-23
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Dashti Y;Nakou IT;Mullins AJ;Webster G;Jian X;Mahenthiralingam E;Challis GL
• 通讯作者: Challis GL