Genetic, lipid and other risk factors in early-onset acute myocardial infarction in Malaysia.

马来西亚早发急性心肌梗塞的遗传、血脂和其他危险因素。

• 批准号: MR/P013880/1
• 负责人: Rajiv Chowdhury
• 金额: $ 25.77万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP013880%2F1
• 关键词: Genetic; lipid; other; risk; factors

Coronary heart disease (CHD), with myocardial infarction (MI) or "heart attack" as the main manifestation, is the leading cause of death worldwide, and is also the leading cause of death in Malaysia. It is estimated that in Malaysia and other South-East Asian countries, nearly a quarter of CHD events occur in people younger than 50 years, resulting in a significant loss of productive working years due to death and disability. This is why we have deigned a case-control study of acute MI in Malaysia to recruit 5000 participants (2500 MI patients or "cases" aged <50 years and 2500 healthy participants or "controls"). In this study, we will initially investigate the hereditary and lipid-related risk factors of heart attack in Malaysia's population - which has distinctive features of multi-ethnicity and consanguinity (or intermarriage). The specific objectives of our proposed study are to:(1) investigate genetic risk factors of premature heart attack in Malaysia;(2) evaluate cardiovascular risk factors of specific relevance to the Malaysian population, such as indigenous forms of tobacco consumption and local dietary patterns, with potential implications of results for public health policy; and(3) create collaborations between Malaysian and UK scientists, who will jointly manage and further harvest the dataset and bioresource of this nationally-important research platform.

以心肌梗死（MI）或“心脏病发作”为主要表现的冠心病（CHD）是世界范围内的主要死亡原因，也是马来西亚的主要死亡原因。据估计，在马来西亚和其他东南亚国家，近四分之一的冠心病病例发生在50岁以下的人群中，导致因死亡和残疾而严重丧失生产工作年限。这就是为什么我们在马来西亚设计了一项急性心肌梗死病例对照研究，招募了5000名参与者（2500名心肌梗死患者或年龄<50岁的“病例”和2500名健康参与者或“对照组”）。在这项研究中，我们将初步调查马来西亚人口中心脏病发作的遗传和脂质相关危险因素-马来西亚人口具有多种族和血缘（或异族婚姻）的显著特征。我们提出的研究的具体目标是：(1)调查马来西亚过早心脏病发作的遗传风险因素；(2)评估与马来西亚人口具体相关的心血管风险因素，如土著形式的烟草消费和当地饮食模式，其结果可能对公共卫生政策产生影响；(3)在马来西亚和英国科学家之间建立合作关系，共同管理和进一步收获这个国家重要研究平台的数据集和生物资源。

项目成果

The Malaysian Acute Vascular Events Risk (MAVERIK) study protocol: studying genetic and other determinants of first-ever myocardial infarction in Malaysia (Preprint)

马来西亚急性血管事件风险 (MAVERIK) 研究方案：研究马来西亚首例心肌梗塞的遗传和其他决定因素（预印本）

• DOI: 10.17863/cam.80250
• 发表时间: 2022
• 作者: Chowdhury R

Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma.

• DOI: 10.1093/hmg/ddx053
• 发表时间: 2017-04-15
• 期刊: Human molecular genetics
• 影响因子: 3.5
• 作者: Farahi N;Paige E;Balla J;Prudence E;Ferreira RC;Southwood M;Appleby SL;Bakke P;Gulsvik A;Litonjua AA;Sparrow D;Silverman EK;Cho MH;Danesh J;Paul DS;Freitag DF;Chilvers ER
• 通讯作者: Chilvers ER

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

• DOI: 10.1038/s41467-018-03109-y
• 发表时间: 2018-02-19
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Corbin LJ;Tan VY;Hughes DA;Wade KH;Paul DS;Tansey KE;Butcher F;Dudbridge F;Howson JM;Jallow MW;John C;Kingston N;Lindgren CM;O'Donavan M;O'Rahilly S;Owen MJ;Palmer CNA;Pearson ER;Scott RA;van Heel DA;Whittaker J;Frayling T;Tobin MD;Wain LV;Smith GD;Evans DM;Karpe F;McCarthy MI;Danesh J;Franks PW;Timpson NJ
• 通讯作者: Timpson NJ

Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study.

• DOI: 10.2196/31885
• 发表时间: 2022-02-10
• 期刊: JMIR research protocols
• 影响因子: 1.7
• 作者: Chowdhury R;Noh MFM;Ismail SR;van Daalen KR;Kamaruddin PSNM;Zulkiply SH;Azizul NH;Khalid NM;Ali A;Idris IM;Mei YS;Abdullah SR;Faridus N;Yusof NAM;Yusoff NNFM;Jamal R;Rahim AAA;Ghapar AKA;Radhakrishnan AK;Fong AYY;Ismail O;Krishinan S;Lee CY;Bang LH;Mageswaren E;Mahendran K;Amin NHM;Muthusamy G;Jin AOH;Ramli AW;Ross NT;Ruhani AI;Yahya M;Yusoff Y;Abidin SKZ;Amado L;Bolton T;Weston S;Crawte J;Ovenden N;Michielsen A;Monower MM;Mahiyuddin WRW;Wood A;Di Angelantonio E;Sulaiman NS;Danesh J;Butterworth AS
• 通讯作者: Butterworth AS

Efficiency and safety of varying the frequency of whole blood donation: randomised trial of 45,000 donors

改变全血捐献频率的效率和安全性：45,000 名捐献者的随机试验

• DOI: 10.17863/cam.13346
• 发表时间: 2017
• 作者: Di Angelantonio E