Genetic, lipid and other risk factors in early-onset acute myocardial infarction in Malaysia.

以心肌梗死（MI）或“心脏病发作”为主要表现的冠心病（CHD）是世界范围内的主要死亡原因，也是马来西亚的主要死亡原因。据估计，在马来西亚和其他东南亚国家，近四分之一的冠心病病例发生在50岁以下的人群中，导致因死亡和残疾而严重丧失生产工作年限。这就是为什么我们在马来西亚设计了一项急性心肌梗死病例对照研究，招募了5000名参与者（2500名心肌梗死患者或年龄<50岁的“病例”和2500名健康参与者或“对照组”）。在这项研究中，我们将初步调查马来西亚人口中心脏病发作的遗传和脂质相关危险因素-马来西亚人口具有多种族和血缘（或异族婚姻）的显著特征。我们提出的研究的具体目标是：(1)调查马来西亚过早心脏病发作的遗传风险因素；(2)评估与马来西亚人口具体相关的心血管风险因素，如土著形式的烟草消费和当地饮食模式，其结果可能对公共卫生政策产生影响；(3)在马来西亚和英国科学家之间建立合作关系，共同管理和进一步收获这个国家重要研究平台的数据集和生物资源。

Coronary heart disease (CHD), with myocardial infarction (MI) or "heart attack" as the main manifestation, is the leading cause of death worldwide, and is also the leading cause of death in Malaysia. It is estimated that in Malaysia and other South-East Asian countries, nearly a quarter of CHD events occur in people younger than 50 years, resulting in a significant loss of productive working years due to death and disability. This is why we have deigned a case-control study of acute MI in Malaysia to recruit 5000 participants (2500 MI patients or "cases" aged <50 years and 2500 healthy participants or "controls"). In this study, we will initially investigate the hereditary and lipid-related risk factors of heart attack in Malaysia's population - which has distinctive features of multi-ethnicity and consanguinity (or intermarriage). The specific objectives of our proposed study are to:(1) investigate genetic risk factors of premature heart attack in Malaysia;(2) evaluate cardiovascular risk factors of specific relevance to the Malaysian population, such as indigenous forms of tobacco consumption and local dietary patterns, with potential implications of results for public health policy; and(3) create collaborations between Malaysian and UK scientists, who will jointly manage and further harvest the dataset and bioresource of this nationally-important research platform.