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VISUAL ADAPTATION IN THE VERTEBRATE RETINA

VISUAL ADAPTATION IN THE VERTEBRATE RETINA
脊椎动物视网膜的视觉适应
批准号：
2888230
负责人：
HARRIS RIPPS
金额：
$41.37万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
项目状态：
已结题
起止时间：
1985-10-01 至 2000-06-30
来源：
https://reporter.nih.gov/project-details/2888230
关键词：
Chondrichthyes GABA receptor Muller's cell catfish dark adaptation electroretinography gap junctions genetically modified animals laboratory mouse molecular cloning retinal bipolar neuron retinoid binding proteins rhodopsin visual photoreceptor

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英文摘要
DESCRIPTION (Adapted from applicant's abstract): This proposal is focused on aspects of visual adaptation in the vertebrate retina. The proposal is divided into three broad aims: (1) to clone, sequence and express connexins from skate and catfish retina and perform functional and comparative studies; (2) to identify, with electrophysiological methods, the GABA receptors of bipolar cells and Muller cells in the skate retina and to examine their modulation; and (3) to assess the role of IRBP in retinal development and the rhodopsin cycle. In the latter aim, a variety of studies will be conducted on transgenic mice with an IRBP knockout or partial expression.
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