The roles of GABA receptor subunits in circadian rhythms in GABA responsiveness in the suprachiasmatic nucleus

GABA 受体亚基在昼夜节律中对视交叉上核 GABA 反应的作用

基本信息

  • 批准号:
    9428043
  • 负责人:
  • 金额:
    $ 0.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-03-01 至 2017-02-28
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Circadian clocks generate endogenous rhythms in nearly all behavior and physiology. Disruption of the entrainment of these clocks to the daily light-dark cycle contributes to a multitude of metabolic, psychiatric, and neurologic disorders. Understanding how the etiology of these disorders is produced by disruptions in entrainment will require understanding the neural mechanisms controlling entrainment in the master circadian clock, which is located in the suprachiasmatic nucleus (SCN). The overall goal of the proposed research is identify neural mechanisms underlying the entrainment of the SCN to the environmental light-dark cycle. Great progress has been made in understanding the translational and transcriptional feedback loops that comprise the molecular clock, yet the specific neurochemical signals that shift the clock during entrainment are not well understood. However, it is clear that GABA is one of these neurochemical signals critical to entrainment of the SCN. The effects of GABA on entrainment of the SCN are phase-specific, however the mechanism underlying this pattern of effects is not known. These studies will test the hypotheses that circadian oscillations in the expression and function between the GABAA2 synaptic receptor and the GABAA extrasynaptic receptor underlie the circadian phase-specific responses of the SCN to GABA during entrainment, and that these receptors differentially mediate induction of the clock gene Period in the SCN. On a larger scale, these studies will provide new information on GABA signaling and the interaction of GABAA receptor subtypes that may be relevant to the action of GABA throughout the CNS. Because many drugs that target the GABA system are used to treat diseases ranging from anxiety disorders to epilepsy, it is clinically important to understand how GABA acts in the brain. Additionally, the training that I will receive in completion of these studies will significantly accelerate my development as a scientist and springboard me to reach my goal as an independent investigator at a research-intensive university.
 描述(由申请人提供):生物钟在几乎所有行为和生理学中产生内源性节律。这些生物钟对日常明暗循环的干扰会导致许多代谢、精神和神经疾病。了解这些疾病的病因是如何产生的干扰夹带将需要了解的神经机制控制夹带在主昼夜节律钟,这是位于视交叉上核(SCN)。这项研究的总体目标是确定SCN夹带到环境光暗周期的神经机制。在理解构成分子钟的翻译和转录反馈回路方面已经取得了很大进展,但在夹带期间改变时钟的特定神经化学信号还没有得到很好的理解。然而,很明显,GABA是对SCN夹带至关重要的神经化学信号之一。GABA对SCN夹带的影响是阶段特异性的,然而这种影响模式的机制尚不清楚。这些研究将测试的假设,昼夜节律振荡的表达和功能之间的GABAA β 2突触受体和GABAA β突触外受体的基础上的昼夜节律相位特异性反应的SCN GABA在夹带期间,这些受体差异介导的时钟基因周期在SCN的诱导。在更大的范围内,这些研究将提供有关GABA信号传导和GABAA受体亚型相互作用的新信息,这些信息可能与GABA在整个CNS中的作用有关。由于许多靶向GABA系统的药物被用于治疗从焦虑症到癫痫的疾病,因此了解GABA在大脑中的作用在临床上非常重要。此外,我所接受的培训 完成这些研究将大大加速我作为一名科学家的发展,并帮助我实现在一所研究型大学成为一名独立研究者的目标。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

James C. Walton其他文献

Estrous phase alters social behavior in a polygynous but not a monogamous <em>Peromyscus</em> species
  • DOI:
    10.1016/j.yhbeh.2010.03.022
  • 发表时间:
    2010-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kate Karelina;James C. Walton;Zachary M. Weil;Greg J. Norman;Randy J. Nelson;A. Courtney DeVries
  • 通讯作者:
    A. Courtney DeVries
Circadian rhythm disruption and mental health
昼夜节律紊乱与心理健康
  • DOI:
    10.1038/s41398-020-0694-0
  • 发表时间:
    2020-01-23
  • 期刊:
  • 影响因子:
    6.200
  • 作者:
    William H. Walker;James C. Walton;A. Courtney DeVries;Randy J. Nelson
  • 通讯作者:
    Randy J. Nelson
Social experience and sex-dependent regulation of aggression in the lateral septum by extrasynaptic δGABAA receptors
社会经验和突触外 δGABAA 受体对外侧隔膜攻击行为的性别依赖性调节
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Johnathan M. Borland;James C. Walton;A. Norvelle;Kymberly N. Grantham;L. M. Aiani;T. Larkin;Katharine E. McCann;H. Albers
  • 通讯作者:
    H. Albers

James C. Walton的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('James C. Walton', 18)}}的其他基金

The roles of GABA receptor subunits in circadian rhythms in GABA responsiveness in the suprachiasmatic nucleus
GABA 受体亚基在昼夜节律中对视交叉上核 GABA 反应的作用
  • 批准号:
    9022330
  • 财政年份:
    2015
  • 资助金额:
    $ 0.02万
  • 项目类别:
The roles of GABA receptor subunits in circadian rhythms in GABA responsiveness in the suprachiasmatic nucleus
GABA 受体亚基在昼夜节律中对视交叉上核 GABA 反应的作用
  • 批准号:
    9198266
  • 财政年份:
    2015
  • 资助金额:
    $ 0.02万
  • 项目类别:
West Virginia University Stroke COBRE
西弗吉尼亚大学中风 COBRE
  • 批准号:
    10217165
  • 财政年份:
    2014
  • 资助金额:
    $ 0.02万
  • 项目类别:

相似海外基金

Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
  • 批准号:
    MR/Y009568/1
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
  • 批准号:
    10090332
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Collaborative R&D
Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
  • 批准号:
    MR/X02329X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Fellowship
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
  • 批准号:
    MR/X021882/1
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
  • 批准号:
    MR/X029557/1
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Research Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
  • 批准号:
    EP/Y003527/1
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
  • 批准号:
    EP/Y030338/1
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
  • 批准号:
    2312694
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Standard Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
  • 批准号:
    24K19395
  • 财政年份:
    2024
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Acute human gingivitis systems biology
人类急性牙龈炎系统生物学
  • 批准号:
    484000
  • 财政年份:
    2023
  • 资助金额:
    $ 0.02万
  • 项目类别:
    Operating Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了