INTERFACIAL ADSORPTION OF PULMONARY SURFACTANT

肺表面活性剂的界面吸附

• 批准号: 6017191
• 负责人: STEPHEN B HALL
• 金额: $ 10.53万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6017191
• 关键词: adsorption; animal extract; biophysics; fatty acylation; high performance liquid chromatography; lung; mathematical model; molecular film; palmitates; phosphatidylcholines; pulmonary surfactants; surface property; thermodynamics; thin layer chromatography

This application requests support to provide a substantial increase in the principal investigator's protected time for research on pulmonary surfactant. The principal investigator (PI) brings to his research a combination of solid training in both physical science and clinical medicine, including a doctorate in biophysical chemistry and a fellowship in pulmonary and critical care medicine. He is currently an assistant professor with extensive clinical, teaching, and administrative responsibilities in addition to his research. He now has eight years of experience in research concerning pulmonary surfactant, including four years as an independent investigator in his own laboratory. These studies have been supported by several grants designed for starting investigators. He currently is PI or co-PI on three peer-reviewed nationally competitive grants, including two from the Whitaker Foundation and a recent First Award from NIH. His research focuses on two critical steps essential for surfactant function. The studies proposed in this application will examine mechanisms by which pulmonary surfactant adsorbs rapidly to form interfacial films. A second project concerns structures within the surface films allow them to remain stable at the interface during compression to very low surface tensions. A manuscript concerning preliminary findings is approaching submission, and specific aims are being formulated for an application to provide grant support. The PI's research emphasizes collaboration with other laboratories which provide access to state-of-the- art methods in interfacial science which have not previously been used to study pulmonary surfactant. The ultimate goal of the PI's research is to extend the successful use of surfactant in neonates to adult patients, and in particular to develop inexpensive effective surfactant to i=minimize the cost of the larger doses required in adults. The funds provided by this grant would increase the PI's commitment to research from 45% to 83%. His only other obligations would be 1-2 seminars and 102 lectures per year on subjects directly relate to his research, and 8 weeks of clinical responsibility which he has requested to maintain his clinical skills. The research proposal is the project funded by a First Award which began one month prior to the submission of the application. The proposed studies will establish mechanisms by which pulmonary surfactant adsorbs rapidly to an air-liquid interface to form interfacial films capable of reducing surface tension during compression.

此应用程序请求支持，以大幅增加 主要研究者的肺研究保护时间 表面活性 首席研究员（PI）为他的研究带来了一个 物理与临床相结合的扎实训练 医学，包括生物物理化学博士学位和研究金 在肺部和重症监护医学。 他目前是一名助理 教授具有广泛的临床，教学和行政 除了他的研究之外。 他现在有八年的 在肺表面活性物质研究方面的经验，包括四个 在自己的实验室里做独立研究员。 这些研究 已经得到了几项为启动研究人员而设计的赠款的支持。 他目前是PI或共同PI的三个同行评审的国家竞争力 赠款，包括惠特克基金会和最近的一个第一奖两个 来自NIH。 他的研究集中在两个关键步骤， 表面活性剂功能。 本申请中提出的研究将审查 肺表面活性物质快速吸附形成 界面膜 第二个项目涉及地表内的结构 薄膜允许它们在压缩过程中在界面处保持稳定， 非常低的表面张力。 关于初步调查结果的手稿是 提交，并正在制定具体目标， 申请提供资助。 PI的研究强调， 与其他实验室合作，提供最新的 界面科学中的现有技术方法以前没有用于 研究肺表面活性物质。 PI研究的最终目标是 将表面活性剂在新生儿中的成功使用扩展到成年患者，以及 特别是开发廉价有效的表面活性剂， 成人所需的较大剂量的成本。 这所提供的资金 拨款将使PI的研究承诺从45%增加到83%。 他 只有其他义务是每年举办1-2次研讨会和102次讲座， 与他的研究直接相关的受试者，以及8周的临床 这是他要求保持临床技能的责任。 该研究提案是由一等奖资助的项目， 在提交申请前一个月。 拟议的研究 将建立肺表面活性物质快速吸附的机制， 气-液界面，以形成能够减少 压缩过程中的表面张力