STRUCTURAL EFFECTS OF HYDROPHOBIC SURFACTANT PROTEINS

疏水表面活性剂蛋白质的结构效应

基本信息

  • 批准号:
    8362124
  • 负责人:
  • 金额:
    $ 0.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-03-01 至 2012-02-29
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pulmonary surfactant is the mixture of lipids and proteins that the lungs secrete to coat the thin layer of liquid that lines the alveolar air spaces. Its function is to lower surface tension, thereby preventing alveolar collapse at the end of exhalation. Two hydrophobic surfactant proteins, SPB and SP-C, which constitute less than 1.5% (w/w) of the complete mixture, are essential for normal function. The proteins promote adsorption of surfactant vesicles to the air/water interface, allowing surfactant films to form within seconds of creating the initial surface when a baby takes its first breath. Despite their importance, the mechanisms by which the proteins facilitate adsorption are uncertain. The proposed studies test hypotheses that follow from a model in which the proteins stabilize a rate-determining, negatively curved structure that bridges the gap between the bilayer of a surfactant vesicle and the air/water interface. Our experiments will determine if: (1) dispersed constituents, which initially form unilamellar vesicles (ULV) that can be detected by small angle X-ray scattering (SAXS), must transform to multilamellar vesicles (MLV), measured by small angle X-ray diffraction (SAXD), to adsorb rapidly; (2) the SPs alter the spontaneous curvature of lipid leaflets, obtained from the d-spacing produced by SAXD from hexagonal-II (HII) structures; (3) the SPs alter the bending modulus, obtained from the shape of the diffraction peaks generated by MLV with and without the proteins.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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STEPHEN B HALL其他文献

STEPHEN B HALL的其他文献

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{{ truncateString('STEPHEN B HALL', 18)}}的其他基金

Therapeutic Surfactants
治疗性表面活性剂
  • 批准号:
    9336483
  • 财政年份:
    2016
  • 资助金额:
    $ 0.55万
  • 项目类别:
STRUCTURAL EFFECTS OF HYDROPHOBIC SURFACTANT PROTEINS
疏水表面活性剂蛋白质的结构效应
  • 批准号:
    8170041
  • 财政年份:
    2010
  • 资助金额:
    $ 0.55万
  • 项目类别:
STRUCTURAL EFFECTS OF HYDROPHOBIC SURFACTANT PROTEINS
疏水表面活性剂蛋白质的结构效应
  • 批准号:
    7954365
  • 财政年份:
    2009
  • 资助金额:
    $ 0.55万
  • 项目类别:
STRUCTURAL EFFECTS OF HYDROPHOBIC SURFACTANT PROTEINS
疏水表面活性剂蛋白质的结构效应
  • 批准号:
    7722026
  • 财政年份:
    2008
  • 资助金额:
    $ 0.55万
  • 项目类别:
STRUCTURAL EFFECTS OF HYDROPHOBIC SURFACTANT PROTEINS
疏水表面活性剂蛋白质的结构效应
  • 批准号:
    7598286
  • 财政年份:
    2007
  • 资助金额:
    $ 0.55万
  • 项目类别:
INTERFACIAL PHASE BEHAVIOR OF PULMONARY SURFACTANT
肺表面活性剂的界面相行为
  • 批准号:
    6390037
  • 财政年份:
    1998
  • 资助金额:
    $ 0.55万
  • 项目类别:
Interfacial Phase Behavior of Pulmonary Surfactant
肺表面活性剂的界面相行为
  • 批准号:
    6779061
  • 财政年份:
    1998
  • 资助金额:
    $ 0.55万
  • 项目类别:
INTERFACIAL PHASE BEHAVIOR OF PULMONARY SURFACTANT
肺表面活性剂的界面相行为
  • 批准号:
    2688229
  • 财政年份:
    1998
  • 资助金额:
    $ 0.55万
  • 项目类别:
INTERFACIAL PHASE BEHAVIOR OF PULMONARY SURFACTANT
肺表面活性剂的界面相行为
  • 批准号:
    6044044
  • 财政年份:
    1998
  • 资助金额:
    $ 0.55万
  • 项目类别:
Interfacial Phase Behavior of Pulmonary Surfactant
肺表面活性剂的界面相行为
  • 批准号:
    6604301
  • 财政年份:
    1998
  • 资助金额:
    $ 0.55万
  • 项目类别:

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