Durable, practical, effective and affordable formats for insecticide-treated eave baffles that protect households and suppress malaria transmission

屋檐挡板（EB）是一种简单的住房改造，使用广泛可用的网状材料，可以用现有的杀虫剂制剂处理。经过处理的EB和窗纱在蚊子进入房屋后将其捕获在房屋内，并在它们试图再次离开时迫使它们与杀虫剂发生致命接触。在坦桑尼亚南部的标准化实验小屋中，经灭疟剂处理的EB的实验原型被证明是杀死疟疾病媒的室内滞留喷洒的等效或上级替代方法。EB需要的杀虫剂比IRS少5倍以上，并且与粘合剂（BA）共处理可以提高耐久性，因此它们只需要每2至3年处理一次。因此，这项早期研究的总体目标是开发新的、实用的、可扩展的EB原型，这些原型已经适应于在进入房屋的蚊子攻击居住者之前捕获它们，并且可以容易地安装在大多数非洲农村房屋中。我们提出了以下目标，为这个早期阶段的研究：1。重新评估先前评估的实验原型EB对An的杀虫功效。funestus和An.在治疗后12、18、24和30个月，在实验小屋中对阿拉伯藜进行治疗，以证明与BA共同治疗时的长期疗效。在坦桑尼亚农村房屋的随机抽样中，以易于制造的“在线”格式开发新的EB诱捕器设计，以及可广泛扩展的安装程序，并展示成功安装，将蚊虫叮咬滋扰减少>80%，并评估用户感知。3.使用实验小屋来测量对蚊子存活的影响，证明可扩展的EB诱捕器形式与先前的实验原型具有等同的杀虫功效。

Eave baffles (EBs) are a simple housing modification using widely-available netting materials, which can be treated with existing insecticide formulations. Treated EBs and window screens trap mosquitoes inside houses after they enter, and force them into lethal contact with insecticides when they attempt to exit again. Experimental prototypes of insecticide-treated EBs proved an equivalent or superior alternative to indoor residual spraying for killing malaria vectors in standardized experimental huts in southern Tanzania. EBs required >5 times less insecticide than IRS, and co-treating with a binding agent (BA) could enhance durability so that they only need to be treated every 2 to 3 years.The overall goal of this early-phase study is therefore to develop new, practical, scalable prototypes for EBs, which have been adapted to trap house-entering mosquitoes before they can attack the occupants, and can be readily installed in most rural African houses. We propose the following objectives for this early-phase study:1. Re-assess the insecticidal efficacy of the previously evaluated experimental prototype EBs against An. funestus and An. arabiensis in experimental huts at 12, 18, 24 and 30 months post-treatment, to demonstrate long-term efficacy when co-treated with BA.2. Develop a new EB trap design in a readily-manufactured "on a roll" format, together with broadly-scalable installation procedures, and demonstrate successful installation that reduces mosquito biting nuisance by >80% and assess user perceptions, in a random sample of rural Tanzanian houses.3. Demonstrate equivalent insecticidal efficacy of the scalable EB trap-on-a-roll format to the previous experimental prototype, using experimental huts to measure impact on mosquito survival.