Durable, practical, effective and affordable formats for insecticide-treated eave baffles that protect households and suppress malaria transmission

耐用、实用、有效且价格实惠的经杀虫剂处理的屋檐挡板，可保护家庭并抑制疟疾传播

• 批准号: MR/P01691X/1
• 负责人: Gerry Killeen
• 金额: $ 19.27万
• 依托单位: Liverpool School of Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP01691X%2F1
• 关键词: Durable; practical; effective; affordable; formats

Eave baffles (EBs) are a simple housing modification using widely-available netting materials, which can be treated with existing insecticide formulations. Treated EBs and window screens trap mosquitoes inside houses after they enter, and force them into lethal contact with insecticides when they attempt to exit again. Experimental prototypes of insecticide-treated EBs proved an equivalent or superior alternative to indoor residual spraying for killing malaria vectors in standardized experimental huts in southern Tanzania. EBs required >5 times less insecticide than IRS, and co-treating with a binding agent (BA) could enhance durability so that they only need to be treated every 2 to 3 years.The overall goal of this early-phase study is therefore to develop new, practical, scalable prototypes for EBs, which have been adapted to trap house-entering mosquitoes before they can attack the occupants, and can be readily installed in most rural African houses. We propose the following objectives for this early-phase study:1. Re-assess the insecticidal efficacy of the previously evaluated experimental prototype EBs against An. funestus and An. arabiensis in experimental huts at 12, 18, 24 and 30 months post-treatment, to demonstrate long-term efficacy when co-treated with BA.2. Develop a new EB trap design in a readily-manufactured "on a roll" format, together with broadly-scalable installation procedures, and demonstrate successful installation that reduces mosquito biting nuisance by >80% and assess user perceptions, in a random sample of rural Tanzanian houses.3. Demonstrate equivalent insecticidal efficacy of the scalable EB trap-on-a-roll format to the previous experimental prototype, using experimental huts to measure impact on mosquito survival.

屋檐挡板（EBs）是一种简单的住房改造，使用广泛可用的网状材料，可以用现有的杀虫剂配方处理。经过处理的电子屏障和纱窗会在蚊子进入房屋后将其困住，并在它们试图再次离开时迫使它们与杀虫剂进行致命接触。在坦桑尼亚南部的标准化实验小屋中，经杀虫剂处理的EBs实验原型证明是与室内残留喷洒杀死疟疾病媒相当或更好的替代方法。与IRS相比，EBs的杀虫剂用量减少了5倍，并且与结合剂（BA）共处理可以提高持久性，因此只需每2至3年处理一次。因此，这一早期阶段研究的总体目标是开发新的、实用的、可扩展的EBs原型，这种原型已经被用于在蚊子攻击居住者之前捕获进入房屋的蚊子，并且可以很容易地安装在大多数非洲农村房屋中。我们为这项早期研究提出以下目标：1。重新评估先前评估的实验原型EBs对安蝇虫的杀虫效果。funestus和An。在处理后12、18、24和30个月的实验小屋中，以证明与BA.2共同处理的长期效果。2 .在坦桑尼亚农村房屋的随机样本中，开发一种易于制造的“卷装”形式的新型EB诱捕器设计，以及可广泛扩展的安装程序，并演示成功安装将蚊虫叮咬危害减少了80%，并评估用户的感受。利用实验小屋测量对蚊子存活的影响，证明可扩展的EB卷捕虫器形式的杀虫效果与先前的实验原型相当。

项目成果

Participatory development of practical, affordable, insecticide-treated mosquito proofing for a range of housing designs in rural southern Tanzania.

• DOI: 10.1186/s12936-022-04333-0
• 发表时间: 2022-11-05
• 期刊: MALARIA JOURNAL
• 影响因子: 3
• 作者: Msoffe, Rogath;Hewitt, Matilda;Masalu, John P.;Finda, Marcelina;Kavishe, Deogratius R.;Okumu, Fredros O.;Mpolya, Emmanuel A.;Kaindoa, Emmanuel W.;Killeen, Gerry F.
• 通讯作者: Killeen, Gerry F.

Participatory Development of Practical, Affordable, Insecticide-Treated Mosquito Proofing for a Range of Housing Designs in Rural Southern Tanzania

为坦桑尼亚南部农村地区的一系列住房设计参与开发实用、经济实惠、经过杀虫剂处理的防蚊技术

• DOI: 10.21203/rs.3.rs-1401593/v1
• 发表时间: 2022
• 作者: Msoffe R