Participatory development of practical, affordable, insecticide-treated mosquito proofing for a range of housing designs in rural southern Tanzania.
Participatory development of practical, affordable, insecticide-treated mosquito proofing for a range of housing designs in rural southern Tanzania.
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DOI：
10.1186/s12936-022-04333-0
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发表时间：
2022-11-05
期刊：
影响因子：
3
通讯作者：
Killeen, Gerry F.
中科院分区：
文献类型：
--
作者：
Msoffe, Rogath;Hewitt, Matilda;Masalu, John P.;Finda, Marcelina;Kavishe, Deogratius R.;Okumu, Fredros O.;Mpolya, Emmanuel A.;Kaindoa, Emmanuel W.;Killeen, Gerry F.
驱虫蚊帐可以联合收割机结合经杀虫剂处理过的蚊帐和室内滞留喷洒这两种目前非洲最重要的病媒控制第一线干预措施的最佳特点，并克服这些方法的最重要局限性。这项研究让坦桑尼亚农村社区的成员参与开发和评估简单、负担得起和可扩展的程序，以便在他们自己房屋的屋檐缝隙和窗户上安装现成的筛选材料，然后用广泛使用的有机磷杀虫剂甲基嘧啶（PM）的IRS制剂处理这些屏幕。一个队列的54户家庭招募同意后，其房屋的结构特征和居住人口进行了调查。室内蚊子密度进行了纵向调查，约3个月前和超过5个月后，参与性的房屋改造和筛选，使用当地可用的材料。将每个房屋随机分配到三个研究组中的一个：（1）直到研究结束才安装筛网（阴性对照），（2）安装未处理的筛网，和（3）安装筛网然后用PM处理，随后使用标准锥孔测定法评估其杀虫活性。几乎所有（52个）被招募的家庭都参加了调查，直到最后，所有房屋都成功地通过了筛查。在大多数情况下，只有在进行了被登记家庭接受的结构改造之后，才安装了筛查。与未筛选的房屋相比，具有经处理或未经处理的屏障的房屋几乎完全排除阿拉伯按蚊（相对减少（RR）≥ 98%，P < < 0.0001），这是当地最丰富的疟疾媒介。然而，无论其治疗状态如何，屏障对致倦库蚊的有效性都要低得多（RR ≤ 46%，P < < 0.0001），致倦库蚊是一种引起相当大的叮咬滋扰的非疟疾媒介。虽然PM并没有增加家庭层面的保护屏幕对蚊子物种（P = 0.676和0.831，分别），治疗后8个月，它仍然导致73%和89%的死亡率易感昆虫饲养的冈比亚按蚊暴露后3和30分钟，分别。对防蚊房屋采取预防性措施可能是可以接受和有效的，安装的纱窗可能是残留杀虫剂处理的适当目标。在线版本包含补充材料，可通过10.1186/s12936-022-04333-0获得。
Insecticidal mosquito-proof netting screens could combine the best features of insecticide-treated nets (ITNs) and indoor residual spraying (IRS), the two most important front line vector control interventions in Africa today, and also overcome the most important limitations of these methods. This study engaged members of a rural Tanzanian community in developing and evaluating simple, affordable and scalable procedures for installing readily available screening materials on eave gaps and windows of their own houses, and then treating those screens with a widely used IRS formulation of the organophosphate insecticide pirimiphos-methyl (PM). A cohort of 54 households recruited upon consent, following which the structural features and occupant demographics of their houses were surveyed. Indoor mosquito densities were surveyed longitudinally, for approximately 3 months before and over 5 months after participatory house modification and screening using locally available materials. Each house was randomly assigned to one of three study arms: (1) No screens installed until the end of the study (negative control), (2) untreated screens installed, and (3) screened installed and then treated with PM, the insecticidal activity of which was subsequently assessed using standard cone assays. Almost all (52) recruited households participated until the end, at which point all houses had been successfully screened. In most cases, screening was only installed after making enabling structural modifications that were accepted by the enrolled households. Compared to unscreened houses, houses with either treated or untreated screens both almost entirely excluded Anopheles arabiensis (Relative reduction (RR) ≥ 98%, P < < 0.0001), the most abundant local malaria vector. However, screens were far less effective against Culex quinquefasciatus (RR ≤ 46%, P < < 0.0001), a non-malaria vector causing considerable biting nuisance, regardless of their treatment status. While PM did not augment household level protection by screens against either mosquito species (P = 0.676 and 0.831, respectively), 8 months after treatment it still caused 73% and 89% mortality among susceptible insectary-reared Anopheles gambiae following exposures of 3 and 30 min, respectively. Participatory approaches to mosquito proofing houses may be acceptable and effective, and installed screens may be suitable targets for residual insecticide treatments. The online version contains supplementary material available at 10.1186/s12936-022-04333-0.
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影响因子：
3
作者：
Killeen GF;Govella NJ;Lwetoijera DW;Okumu FO
通讯作者：
Okumu FO
影响因子：
8.1
作者：
Killeen GF;Kiware SS;Okumu FO;Sinka ME;Moyes CL;Massey NC;Gething PW;Marshall JM;Chaccour CJ;Tusting LS
通讯作者：
Tusting LS
影响因子：
7.7
作者：
Huho, Bernadette;Briet, Olivier;Killeen, Gerry
通讯作者：
Killeen, Gerry
DOI：
10.4269/ajtmh.2003.68.121
发表时间：
2003-04-01
影响因子：
3.3
作者：
Hawley, WA;Phillips-Howard, PA;Hightower, AW
通讯作者：
Hightower, AW
影响因子：
3
作者：
Kaindoa EW;Finda M;Kiplagat J;Mkandawile G;Nyoni A;Coetzee M;Okumu FO
通讯作者：
Okumu FO