CORONARY REACTIVITY AND OXIDATIVE STRESS

冠状动脉反应性和氧化应激

• 批准号: 2561243
• 负责人: Joseph A. Vita
• 金额: $ 26.08万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2561243
• 关键词: acetylcholine; angiography; antioxidants; ascorbate; atherosclerosis; biomarker; chemoprevention; coronary disorder; cyclic GMP; heart circulation; heart disorder chemotherapy; human subject; human therapy evaluation; injection /infusion; low density lipoprotein; nitric oxide; oxidative stress; substance P; superoxide dismutase; ultrasound blood flow measurement; vascular endothelium; vasodilators; vasomotion

DESCRIPTION: This is a resubmitted grant application to study endothelium- dependent relaxation in the coronary circulation of patients with coronary atherosclerosis. The application emphasizes the relationship of abnormalities in redox state and the generation and release of EDRF in these patients. Endothelium-dependent vasomotion will be studied in response to infusions of acetylcholine and substance P and increased blood flow during cardiac pacing. Vasomotor responses will assessed using intracoronary Doppler and quantitative angiography. These responses will be related to markers of antioxidant protection and oxidative stress in the coronary vasculature (coronary sinus concentrations of F2-isoprostanes and endothelin) and the systemic circulation (plasma antioxidant content and LDL susceptibility to oxidation). To examine the contribution of superoxide production to abnormal coronary activity, vasomotor responses will be examined following treatment with specific inhibitors of superoxide action.

描述：这是一份重新提交的研究资助申请 冠状循环内皮依赖性舒张 冠状动脉粥样硬化患者。申请书强调， 氧化还原状态异常与生成和 在这些患者中释放EDRF。 将研究内皮依赖性血管舒缩反应， 乙酰胆碱和P物质的输注以及血流量的增加 在心脏起搏期间。血管反应将使用 冠状动脉内多普勒和定量血管造影。 这些响应 将与抗氧化保护和氧化标志物相关 冠状血管系统中的应力（冠状窦浓度 F2-异前列腺素和内皮素）和体循环（血浆 抗氧化剂含量和LDL对氧化的敏感性）。审查 超氧化物产生在冠状动脉病变中作用 治疗后将检查血管活性、血管反应 超氧化物作用的特异性抑制剂。