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PHYSIOLOGY OF MOTOR UNITS IN A HUMAN UPPER AIRWAY MUSCLE

人类上呼吸道肌肉运动单位的生理学

基本信息

批准号：
2714048
负责人：
Ralph Frank Fregosi
金额：
$ 15.11万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-07-10 至 2000-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2714048
关键词：
electromyography electrostimulus evoked potentials exercise fatigue human subject motor neurons muscle contraction nerve threshold neural recruitment neural transmission respiratory muscles

项目摘要

The upper airway muscles of the nose, mouth, tongue and larynx control respiratory airflow resistance, and contract rhythmically in phase with breathing. Despite their significance, information about the physiological properties of upper airway motor units and their role in the gradation of muscle force is unavailable. - The proposed studies are designed to provide fundamental information about the neurophysiology of the nasal dilator muscle motoneurOn pool in healthy human subjects. The nasal dilator muscle was chosen as the experimental model because it is involved in controlling the breath-by-breath diameter of the nasal airway, it is readily accessible in humans, and it responds to reflex-mediated ventilatory stimuli in a manner analogous to the upper airway muscles of the larynx, tongue and face. The Specific Aims include: l) to estimate the number of motor units in the nasal dilator muscles; 2) to determine if the nasal dilator motoneuron pool behaves in accordance with the Size Principle, as occurs in limb muscle; 3) to determine the contributions of rate modulation and motor unit recruitment to the gradation of muscle force; 4) to determine the relationship between the neural drive to the nasal dilator muscles, and the force produced by these muscles during rhythmic, involuntary contractions; and to estimate the relative contributions of motor unit recruitment and rate modulation to the rhythmic force variations; and 5) to determine the contractile and endurance properties of these muscles. The measurements to be made include muscle force, single motor unit electrophysiology, muscle twitch properties and evoked potentials, and spike-triggered average force of single motor units in conscious human subjects. There is great clinical interest in upper airway muscle physiology because malfunction of these muscles often initiates or exacerbates the obstructive sleep apnea syndrome. This syndrome is associated with hypoxia and respiratory acidosis, acute and chronic hypertension, and often results in death in both infants and the elderly. These studies will contribute to our understanding of upper airway muscle physiology, and will provide the foundation for the development of treatment strategies.

鼻、口、舌和喉的上呼吸道肌肉控制呼吸气流阻力，并有节奏地收缩，呼吸了尽管它们的重要性，关于生理学的信息上呼吸道运动单位的特性及其在上呼吸道运动分级中的作用肌肉力量不可用。- 拟议的研究旨在提供有关鼻神经生理学的基本信息，健康人受试者的扩张肌运动神经元。鼻选择扩张肌作为实验模型，因为它涉及在控制鼻气道的逐呼吸直径时，在人类中很容易接触到，它对反射介导的以类似于上呼吸道肌肉的方式进行呼吸刺激，喉咙舌头和脸具体目标包括：（1）估计鼻扩张肌中的运动单位数量; 2）确定鼻扩张肌中的鼻扩张器运动神经元池的行为符合尺寸原则，如发生在肢体肌肉; 3）确定的贡献，速率调节和运动单位募集到肌肉的分级力; 4）确定神经驱动与鼻扩张肌，以及这些肌肉在鼻扩张过程中产生的力。有节奏的，不自主的收缩;并估计相对运动单位募集和速率调节对运动神经元功能的影响节律性力变化;和5）确定收缩和这些肌肉的耐力特性。要进行的测量包括肌肉力量、单个运动单位电生理学、肌肉抽搐特性和诱发电位，以及有意识的人类受试者的单个运动单位。有很大的临床对上呼吸道肌肉生理学感兴趣，因为这些肌肉经常引发或加重阻塞性睡眠呼吸暂停综合征这种综合征与缺氧和呼吸系统疾病有关。酸中毒，急性和慢性高血压，并经常导致死亡，包括婴儿和老人。这些研究将有助于我们了解上呼吸道肌肉生理学，并将提供为制定治疗策略奠定基础。

项目成果

期刊论文数量（21）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Contractile properties of human nasal dilator motor units.

人鼻扩张器运动单位的收缩特性。

DOI：
10.1152/jn.1998.79.1.371
发表时间：
1998
期刊：
Journal of neurophysiology.
影响因子：
0
作者：
Mateika,JH;Essif,EG;Dellorusso,C;Fregosi,RF
通讯作者：
Fregosi,RF

Motor unit number in a small facial muscle, dilator naris.

DOI：
10.1007/s00221-015-4359-9
发表时间：
2015-10
期刊：
Experimental brain research
影响因子：
2
作者：
Patel-Khurana N;Fregosi RF
通讯作者：
Fregosi RF

Mechanisms of force failure during repetitive maximal efforts in a human upper airway muscle.

人类上呼吸道肌肉重复最大努力过程中力衰竭的机制。

DOI：
10.1002/mus.10167
发表时间：
2002
期刊：
Muscle & nerve.
影响因子：
0
作者：
DelloRusso,Christiana;Khurana,Nilam;Rankin,Lucinda;Sullivan,Jenna;Fregosi,RalphF
通讯作者：
Fregosi,RalphF

Endurance training of respiratory muscles improves cycling performance in fit young cyclists.