权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neuromuscular control of the mammalian tongue

哺乳动物舌头的神经肌肉控制

基本信息

批准号：
8011373
负责人：
Ralph Frank Fregosi
金额：
$ 30.15万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-01 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8011373
关键词：
Address Adult Agonist Animals Automobile Driving Behavior Breathing Cells Cephalic Code Cranial Nerves Data Deglutition Electrophysiology (science)Face Feedback Fiber Goals Homeostasis Human Individual Intercostal Muscles Laboratories Mammals Mastication Measurement Measures Mechanical ventilation Mechanics Mechanoreceptors Methods Modeling Motor Motor Neurons Movement Muscle Neuraxis Neurons Obstructive Sleep Apnea Output Pathway interactions Pattern Phase Physiological Physiology Population Positioning Attribute Property Rattus Recruitment Activity Relative (related person)Research Personnel Respiration Respiratory Diaphragm Respiratory Muscles Respiratory System Rodent Shapes Skeletal Muscle Source Specificity Speech Spinal Structure Synapses System Techniques Testing Time Tongue Training Variant Work base central pattern generator driving behavior expiration falls human data in vivo Model insight knowledge base motor control motor deficit neuromuscular pharynx muscle pressure receptor relating to nervous system research study respiratory treatment strategy

项目摘要

The tongue muscles participate in such diverse activities as breathing, swallowing, speech and mastication, and are thus critical for homeostasis. Fibers from eight different muscles insert into the mammaliantongue and control its movement, shape and stiffness, but the control of tongue muscle motor units has been largely ignored. Our goal is to explore how the central nervous system controls a patterned behavior (drive controlled by the respiratory central pattern generator, CPG) that involves multiple muscles acting on a single mechanical structure, by addressing the following issues: 1) motoneurons driving tongue protrudor and retractor muscles receive significant common synaptic input even though they have opposite mechanical actions on the tongue, suggesting that agonist-antagonist co-activation controlstongue stiffness; 2) respiratory-related input to tongue and "primary" inspiratory muscles (diaphragm, intercostals) is derived from independent sources; 3) Models predict that motor unit spike trains become more variable as synaptic input to the cell is increased. This can be tested by measuring the change in spike train variability when excitatory synaptic input is superimposed on the underlying input emanating from the respiratory CPG; 4} Motor units innervating tongue muscles with respiratory related activity fall into two functional populations; those that rate code when drive to the muscle increases, and those that do not. Wepropose that the firing rate of motor units that do not rate code saturates despite increases in synaptic input; and we will test this hypothesis; 5) Individual motor units within a muscle comprise at least four, task-specific sub- populations (inspiratory, expiratory, tonic and expiratory-inspiratory units), and the task specificity of a given unit depends on its contractile properties. Experiments will be done in anesthetized, spontaneously breathing adult rats. Techniques used include single motor unit electrophysiology, cross correlation analysis and the measurement of ventilatory output. The results of these experimentswill contribute to the knowledge base needed to develop treatment strategies for obstructive sleep apnea, swallowingdisorders, and oro-facial motor deficits.

舌肌参与呼吸、吞咽、言语和咀嚼等多种活动，因此对于体内平衡至关重要。来自八种不同肌肉的纤维插入哺乳动物的舌头并控制其运动、形状和硬度，但舌肌运动单位的控制已被很大程度上被忽视了。我们的目标是探索中枢神经系统如何控制模式化行为（驱动力）由呼吸中枢模式发生器（CPG）控制，涉及多个肌肉作用于单一的机械结构，通过解决以下问题：1）运动神经元驱动舌头突出和牵开肌接收显着的共同突触输入，即使它们具有相反的对舌头的机械作用，表明激动剂-拮抗剂共同激活控制舌头刚性; 2) 舌头和“主要”吸气肌（膈肌、肋间肌）的呼吸相关输入是来自独立来源； 3) 模型预测运动单位尖峰序列变得更加可变，因为细胞的突触输入增加。这可以通过测量尖峰序列变异性的变化来测试当兴奋性突触输入叠加在来自呼吸系统的潜在输入上时消费品； 4} 与呼吸相关的活动支配舌头肌肉的运动单位分为两种功能人口；那些在肌肉驱动力增加时对代码进行评分的人，以及那些不这样做的人。我们建议尽管突触输入增加，但不对代码进行评级的运动单元的放电率饱和；而我们将检验这个假设； 5) 肌肉内的各个运动单位至少包含四个特定于任务的子单元群体（吸气、呼气、强直和呼气-吸气单位）以及给定任务的特殊性单位取决于其收缩特性。实验将在麻醉状态下自发进行呼吸成年大鼠。使用的技术包括单运动单元电生理学、互相关分析和测量通气量。这些实验的结果将有助于制定阻塞性睡眠呼吸暂停、吞咽障碍、和口面部运动缺陷。