MRI IDENTIFICATION OF FIBROUS CAP ATROPHY AND RUPTURE

纤维帽的破裂是导致 血栓栓塞并发症的管腔表面先进的 动脉粥样硬化斑块 为牙菌斑奠定基础的因素 破坏包括进行性帽萎缩伴细胞损失， 矩阵 不幸的是，这些信念很难测试，因为缺乏 动物模型。 我们建议通过一个 结合人体组织和动物模型的跨学科方法 对可能构成这一过程的分子途径的研究。 在这 项目，我们将研究，使用高分辨率磁共振 影像学，中度颈内动脉狭窄患者队列 狭窄 我们将测试的假设，这些纤维帽 病变通常较厚， 斑块扩大而管腔变窄。 我们还将确定 是否评估缺血性神经系统事件或斑块破裂， 与纤维帽相关的切除斑块的组织学评价 变薄

The rupture of the fibrous cap is the critical event leading to thromboembolic complications on the luminal surface of advanced atherosclerotic plaques. The factors that set the stage for plaque disruption include progressive cap atrophy with loss of cells and matrix. Unfortunately, these beliefs are hard to test because of a lack of animal models. We propose to solve this problem by an interdisciplinary approach combining human tissue and animal model studies of molecular pathways that could underlie this process. In this project, we will study, using high-resolution magnetic resonance imaging, a cohort of patients with moderate internal carotid artery stenosis. We will test the hypothesis that the fibrous caps of these lesions generally are thick and that thinning of the cap develops after the plaque enlarges and the lumen narrows. We will also determine whether ischemic neurological events or plaque rupture assessed by histological evaluation of excised plaques correlates with fibrous cap thinning.