PET/MRI of atherosclerosis

动脉粥样硬化的 PET/MRI

• 批准号: 8028896
• 负责人: THOMAS HATSUKAMI
• 金额: $ 20.75万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8028896
• 关键词: Address; Adipose tissue; Animals; Area; Arterial Fatty Streak; Atherosclerosis; Biology; Carotid Artery Plaques; Carotid Atherosclerotic Disease; Carotid Endarterectomy; Characteristics; Clinical; Development; Diagnosis; Disease; Evaluation; Event; Exhibits; Future; Goals; Gold; Histopathology; Human; Image; Imaging technology; Inflammation; Intervention; Lesion; Magnetic Resonance Imaging; Measurement; Methodology; Methods; Molecular; Morphology; Motivation; Nature; Pathology; Patients; Perfusion; Pharmacologic Substance; Positron-Emission Tomography; Protocols documentation; Recruitment Activity; Research; Resolution; Risk; Rupture; Signal Transduction; Source; Specimen; Stratification; Symptoms; Techniques; Testing; Tissues; Tracer; base; disease natural history; fluorodeoxyglucose; fluorodeoxyglucose positron emission tomography; high risk; imaging modality; improved; in vivo; macrophage; meetings; multimodality; response; uptake

DESCRIPTION (provided by applicant): The central goal of our research is to reduce complications from atherosclerotic disease through the development of imaging technologies. We have previously developed an extensive capability to investigate carotid atherosclerosis via magnetic resonance imaging (MRI). However, our studies have also shown that some aspects of atherosclerotic disease are not easily imaged by MRI, leading us to pursue a multimodality imaging strategy. Most notably, positron emission tomography (PET) scanning offers the possibility to use molecular tracers such as FDG in human studies of atherosclerosis. Thus, combining the capabilities of MRI and PET imaging may offer a more complete picture of atherosclerotic plaque biology. Despite the promise of FDG-PET imaging, considerable challenges exist, most notably related to spatial resolution. Therefore, our central motivation in this proposal is to develop a technique that leverages the high-resolution morphological and perfusion information of MRI to help differentiate the source of FDG-PET signals in carotid atherosclerosis. To investigate this concept, we will utilize high-resolution micro-PET imaging to establish a gold standard of localized signal in ex vivo carotid endarterectomy (CEA) specimens. PUBLIC HEALTH RELEVANCE: In order for vessel wall imaging methods to meet the clinical need for improved stratification of risk in patients with established lesions of atherosclerosis, those methods must address the underlying pathology that leads to those events. While magnetic resonance imaging provides exceptional information on atherosclerotic plaque morphology, positron emission tomography may be better suited for evaluation of plaque biology, particularly inflammation. The goal of this proposal is to develop a quantitative, reliable, and comprehensive combined MRI PET approach for characterizing carotid artery plaque and inflammation.

描述（由申请人提供）：我们研究的中心目标是通过发展成像技术来减少动脉粥样硬化疾病的并发症。我们已经开发了一种通过磁共振成像（MRI）来研究颈动脉粥样硬化的广泛能力。然而，我们的研究也表明，动脉粥样硬化疾病的某些方面不容易通过MRI成像，这导致我们寻求多模态成像策略。最值得注意的是，正电子发射断层扫描（PET）提供了在人类动脉粥样硬化研究中使用FDG等分子示踪剂的可能性。因此，结合MRI和PET成像的能力可以提供更完整的动脉粥样硬化斑块生物学图像。尽管FDG-PET成像前景光明，但仍存在相当大的挑战，尤其是在空间分辨率方面。因此，我们的核心动机是开发一种技术，利用MRI的高分辨率形态学和灌注信息来帮助区分颈动脉粥样硬化中FDG-PET信号的来源。为了研究这一概念，我们将利用高分辨率微pet成像来建立离体颈动脉内膜切除术（CEA）标本中局部信号的金标准。