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m-Africa: Building mobile phone-connected diagnostics and online care pathways to support HIV prevention and management in decentralised settings.

m-Africa：建立与移动电话连接的诊断和在线护理途径，以支持分散环境中的艾滋病毒预防和管理。

基本信息

批准号：
MR/P024378/1
负责人：
Rachel McKendry
金额：
$ 77.26万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FP024378%2F1
关键词：
Africa Building mobile phone connected

项目摘要

m-Africa's long term vision is to build user-friendly, mobile phone-connected HIV tests which link to online pathways for prevention and medical care. These systems will be used by people within their own homes and communities and they can be set up quickly in South African communities hardest hit by HIV. This will enable people to take full advantage of recent breakthroughs in HIV care and ultimately empower those at greatest risk to manage their own health. The United Nations aims to end the HIV/AIDS epidemic by 2030. Yet despite huge advances in HIV treatment, prevention and care, many countries lack the set up to roll them out on a large scale and many people remain afraid of testing and seeking care.South Africa is the country most affected by HIV; almost seven million people are living with HIV and 300,000 people acquire HIV each year. The province of KwaZulu-Natal, home to The Africa Health Research Institute (AHRI), is particularly hard hit. Forty five percent of women attending antenatal clinics have HIV and only half of all people diagnosed with HIV go for medical care within the following year. AHRI research showed that regular home-based HIV testing and immediate treatment could reduce HIV and prolong lives, but getting young people into clinic once they had been diagnosed was hugely challenging. This was because young people felt judged and looked down on once others knew they had HIV. Also they simply couldn't afford to miss work in order to come for an appointment. The aim of m-Africa is to build a new generation of mobile phone-connected HIV diagnostic tests together with an online app that allows a person, from within their home or local community, to get their test results and medical care online. This could even include getting HIV drugs for prevention or treatment. This would allow people to test with more privacy, avoiding the clinic visits they find so difficult. South Africans have more smartphones than people in almost any other African country. We want to take advantage of this to enable more people to get tested, especially those who have never tested before. But in order for these exciting new ideas to succeed we have to develop solutions which people at risk of HIV, health care professionals and government find appealing. So our research will start by asking people from these groups for their opinions on our ideas. We will use focus groups, individual interviews and questions in a regular AHRI household survey of 100,000 people. In parallel we will develop and ask people to test out diagnostic test prototypes, which will include looking at how new ultra-sensitive "nanomaterial" tests could best work. These can detect HIV at the very early stages of infection, when transmission is most likely and prevention most important. We will also design apps to interpret already available HIV tests, which could link results to a doctor for online care. We will engage with key stakeholders from the outset, including the Community Advisory Board, Directorate of Health KwaZulu Natal, industry, policy makers and regulators, to ensure we develop solutions that will be quickly put into practice. This is important because the technologies we develop could be applied across a wide range of infections and medical conditions. This plan is very much in line with the South African mobile health strategy. Our team brings together outstanding clinicians, scientists, engineers and public health researchers from South Africa and the UK, with the primary goal of improving HIV prevention and care to deliver major health and economic benefits at the global epicentre of HIV.

m-Africa 的长期愿景是建立用户友好的、与手机连接的艾滋病毒测试，该测试与在线预防和医疗途径相连接。这些系统将供人们在自己的家庭和社区内使用，并且可以在受艾滋病毒影响最严重的南非社区迅速建立起来。这将使人们能够充分利用艾滋病毒护理方面的最新突破，并最终使那些面临最大风险的人能够管理自己的健康。联合国的目标是到 2030 年结束艾滋病毒/艾滋病的流行。然而，尽管在艾滋病毒治疗、预防和护理方面取得了巨大进步，但许多国家缺乏大规模推广这些措施的设施，许多人仍然害怕检测和寻求护理。南非是受艾滋病毒影响最严重的国家；近 700 万人感染艾滋病毒，每年有 30 万人感染艾滋病毒。非洲健康研究所（AHRI）所在地夸祖鲁-纳塔尔省受到的打击尤其严重。去产前诊所就诊的妇女中有 45% 感染了艾滋病毒，而诊断出艾滋病毒感染者中只有一半会在接下来的一年内接受医疗护理。 AHRI 研究表明，定期家庭艾滋病毒检测和立即治疗可以减少艾滋病毒并延长生命，但年轻人一旦被诊断出就进入诊所就诊是一项巨大的挑战。这是因为一旦其他人知道他们感染了艾滋病毒，年轻人就会感到受到评判和瞧不起。而且他们根本无法承受为了赴约而误工的后果。 m-Africa 的目标是构建新一代与手机连接的艾滋病毒诊断测试以及在线应用程序，该应用程序允许人们在家庭或当地社区内在线获取测试结果和医疗护理。这甚至可能包括获得艾滋病毒药物来预防或治疗。这将使人们能够在更私密的情况下进行测试，从而避免他们觉得困难的诊所就诊。南非人拥有的智能手机比几乎所有其他非洲国家的人都多。我们希望利用这一点，让更多的人接受检测，特别是那些以前从未检测过的人。但为了使这些令人兴奋的新想法取得成功，我们必须开发出对艾滋病毒高危人群、医疗保健专业人员和政府有吸引力的解决方案。因此，我们的研究将首先询问这些群体的人们对我们想法的看法。我们将在对 100,000 人进行的定期 AHRI 家庭调查中使用焦点小组、个人访谈和问题。与此同时，我们将开发并要求人们测试诊断测试原型，其中包括研究新的超灵敏“纳米材料”测试如何最好地发挥作用。这些可以在感染的早期阶段检测出艾滋病毒，此时传播最有可能，预防也最重要。我们还将设计应用程序来解释现有的艾滋病毒检测，这可以将结果与医生联系起来进行在线护理。我们将从一开始就与主要利益相关者合作，包括社区咨询委员会、夸祖鲁纳塔尔省卫生局、行业、政策制定者和监管机构，以确保我们开发出能够快速付诸实践的解决方案。这很重要，因为我们开发的技术可以应用于广泛的感染和医疗状况。这一计划非常符合南非移动医疗战略。我们的团队汇集了来自南非和英国的杰出临床医生、科学家、工程师和公共卫生研究人员，其主要目标是改善艾滋病毒预防和护理，以在全球艾滋病毒中心提供重大健康和经济效益。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Validity of self-testing at home with rapid SARS-CoV-2 antibody detection by lateral flow immunoassay

通过侧流免疫分析快速检测 SARS-CoV-2 抗体在家进行自我检测的有效性

DOI：
10.1101/2022.06.08.22276154
发表时间：
2022
期刊：
影响因子：
0
作者：
Atchison C
通讯作者：
Atchison C

A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing.

DOI：
10.1128/spectrum.00610-21
发表时间：
2021-12-22
期刊：
Microbiology spectrum
影响因子：
3.7
作者：
Gliddon HD;Frampton D;Munsamy V;Heaney J;Pataillot-Meakin T;Nastouli E;Pym AS;Steyn AJC;Pillay D;McKendry RA
通讯作者：
McKendry RA

Thermodynamic analysis of an entropically driven, high-affinity nanobody-HIV p24 interaction.

DOI：
10.1016/j.bpj.2022.12.019
发表时间：
2023-01-17
期刊：
BIOPHYSICAL JOURNAL
影响因子：
3.4
作者：
Brookes, Jennifer C.;Gray, Eleanor R.;Loynachan, Colleen N.;Gut, Michelle J.;Miller, Benjamin S.;Brogan, Alex P. S.;McKendry, Rachel A.
通讯作者：
McKendry, Rachel A.

Tumor-Targeting Cholesterol-Decorated DNA Nanoflowers for Intracellular Ratiometric Aptasensing.