EPSRC Digital Health Hub for Antimicrobial Resistance

EPSRC 抗菌素耐药性数字健康中心

基本信息

  • 批准号:
    EP/X031276/1
  • 负责人:
  • 金额:
    $ 534.6万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    未结题

项目摘要

The Digital Health Hub for Antimicrobial Resistance (AMR) aims to harness innovative digital technologies to ultimately transform antimicrobial one-health surveillance and antimicrobial stewardship, recognising the interconnectedness of AMR between humans, animals and the environment.The World Health Organization declared AMR - also known as the 'silent pandemic' - a top 10 global public health threat facing humanity. AMR also ranks on the UK Cabinet Office Risk Register and yet despite this recognition, there remains alarmingly low levels of attention and funding for AMR prevention. The 2016 O'Neill Review on Antimicrobial Resistance highlights that by 2050, 10 million lives a year and a cumulative US$100 trillion of economic output are at risk unless action is taken to reduce AMR. Resistant pathogens from animals, humans and food can be cross-transmitted and environmental reservoirs are a potentially important domain in which the mobilisation and transfer of resistant genes occur. Thus, an integrated One Health approach to AMR surveillance and public health action is needed. Moreover, there is growing concern that climate change could increase the risk of emerging and re-emerging infectious diseases.There is growing recognition of the importance of data science and digital health technologies in the fight against AMR, though the field remains in its infancy. The COVID-19 pandemic has dramatically accelerated advances in digital health technologies, driven by unprecedented need, and there is a huge opportunity to leverage these advances for AMR. However, there remain many challenges: poor understanding of one-health needs; data linkage, silos and gaps hinder surveillance; the lack of rapid tests, the lack of public awareness of AMR; digital interventions often do not prioritise user-led design and are not grounded in behaviour change; data privacy, security and ethical issues of bringing together large datasets; health inequalities and the digital divide; the disconnect between early stage research and AMR needs, and lack of understanding of how digital technologies can be commercialised, regulated and integrated into health systems and patient pathways.The Digital Health Hub for AMR brings together a critical mass of Co-Is working across traditional disciplines for AMR, including computer science, biomedical engineering, behavioural social science, environmental science, data visualisation, and clinical and public health research, from five universities, NHS, UK Health Security Agency, Centre for Ecology and Hydrology, charities and industry partners. Our hub vision will be achieved through five objectives:1. Systems-level needs: To nurture a new culture of cross-sector engagement to accelerate the creation and adoption of digital health innovations for AMR one-health surveillance and antimicrobial stewardship. 2. Skills and Capacity: To grow interdisciplinary skills, capacity, knowledge sharing and leadership needed to deliver a world-leading digital health strategy for combatting AMR.3. Grand Challenges: To co-create digital health solutions for two AMR grand challenges: i) Digital one-health surveillance of antibiotic use and AMR, linking human, animal and environmental data ii) Digital antimicrobial stewardship via decision support algorithms, digital diagnostics wearables and sensors4. Partnership Fund: To grow critical mass and a hub of innovation by seeding interdisciplinary pilot studies between industry, academia, health and social care.5. Impact and Engagement: To maximise hub impact and EPSRC's investment through our communications strategy, patient and public engagement, biannual conferences and events.
抗菌素耐药性数字健康中心 (AMR) 旨在利用创新的数字技术,最终改变抗菌单一健康监测和抗菌管理,认识到抗菌素耐药性在人类、动物和环境之间的相互关联性。世界卫生组织宣布抗菌素耐药性(也称为“无声流行病”)是人类面临的十大全球公共卫生威胁。抗菌素耐药性也在英国内阁办公室风险登记册中名列前茅,但尽管如此,人们对抗菌素耐药性预防的关注度和资金水平仍然低得惊人。 2016 年奥尼尔抗菌素耐药性审查强调,到 2050 年,除非采取行动减少抗菌素耐药性,否则每年将有 1000 万人丧生,累计 100 万亿美元的经济产出将面临风险。来自动物、人类和食物的耐药病原体可以交叉传播,环境储存库是耐药基因动员和转移发生的潜在重要领域。因此,需要采用一种综合的“同一个健康”方法来进行抗菌素耐药性监测和公共卫生行动。此外,人们越来越担心气候变化可能会增加新出现和重新出现的传染病的风险。人们越来越认识到数据科学和数字健康技术在对抗抗菌素耐药性方面的重要性,尽管该领域仍处于起步阶段。在前所未有的需求的推动下,COVID-19 大流行极大地加速了数字医疗技术的进步,并且有巨大的机会利用这些进步来实现抗微生物药物耐药性。然而,仍然存在许多挑战:对单一健康需求了解不足;数据链接、孤岛和差距阻碍了监测;缺乏快速检测,公众缺乏对抗菌素耐药性的认识;数字干预通常不优先考虑用户主导的设计,也不以行为改变为基础;汇集大型数据集的数据隐私、安全和道德问题;健康不平等和数字鸿沟;早期研究与 AMR 需求之间的脱节,以及对如何将数字技术商业化、监管和整合到卫生系统和患者路径中缺乏了解。 AMR 数字健康中心汇集了来自五所大学、NHS、英国卫生安全局、AMR 中心、跨传统学科的 AMR 工作的关键群体,包括计算机科学、生物医学工程、行为社会科学、环境科学、数据可视化以及临床和公共卫生研究。 生态和水文学、慈善机构和行业合作伙伴。我们的中心愿景将通过五个目标来实现:1。系统级需求:培育跨部门参与的新文化,以加速针对抗菌药物耐药性单一健康监测和抗菌药物管理的数字健康创新的创建和采用。 2. 技能和能力:提高跨学科技能、能力、知识共享和领导力,以制定世界领先的抗击 AMR.3 数字卫生战略。重大挑战:共同创建数字健康解决方案,应对两项 AMR 重大挑战:i) 抗生素使用和 AMR 的数字化单一健康监测,将人类、动物和环境数据联系起来 ii) 通过决策支持算法、数字诊断可穿戴设备和传感器进行数字抗菌管理4。合作基金:通过在工业界、学术界、健康和社会关怀之间开展跨学科试点研究,扩大临界规模和创新中心。5。影响力和参与度:通过我们的沟通策略、耐心和公众参与、每两年一次的会议和活动,最大限度地提高中心影响力和 EPSRC 的投资。

项目成果

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Rachel McKendry其他文献

Rachel McKendry的其他文献

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{{ truncateString('Rachel McKendry', 18)}}的其他基金

i-sense: EPSRC IRC in Agile Early Warning Sensing Systems for Infectious Diseases and Antimicrobial Resistance
i-sense:EPSRC IRC 在传染病和抗菌素耐药性敏捷预警传感系统中的应用
  • 批准号:
    EP/R00529X/1
  • 财政年份:
    2018
  • 资助金额:
    $ 534.6万
  • 项目类别:
    Research Grant
m-Africa: Building mobile phone-connected diagnostics and online care pathways to support HIV prevention and management in decentralised settings.
m-Africa:建立与移动电话连接的诊断和在线护理途径,以支持分散环境中的艾滋病毒预防和管理。
  • 批准号:
    MR/P024378/1
  • 财政年份:
    2017
  • 资助金额:
    $ 534.6万
  • 项目类别:
    Research Grant
EPSRC IRC in Early-Warning Sensing Systems for Infectious Diseases
EPSRC IRC 在传染病预警传感系统中的应用
  • 批准号:
    EP/K031953/1
  • 财政年份:
    2013
  • 资助金额:
    $ 534.6万
  • 项目类别:
    Research Grant
Multi-marker Nanosensors for HIV
HIV 多标记纳米传感器
  • 批准号:
    EP/G062064/1
  • 财政年份:
    2009
  • 资助金额:
    $ 534.6万
  • 项目类别:
    Research Grant
Biosensing with holographic smart chips
全息智能芯片生物传感
  • 批准号:
    EP/D505925/1
  • 财政年份:
    2006
  • 资助金额:
    $ 534.6万
  • 项目类别:
    Research Grant

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Clinitouch-360:数字健康平台,可为初级保健中的抑郁和焦虑患者提供强大的端到端护理
  • 批准号:
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