ST LOUIS BREAST TISSUE REGISTRY

圣路易斯乳腺组织登记处

• 批准号: 2895094
• 负责人: BARBARA A ZEHNBAUER
• 金额: $ 21.26万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2895094
• 关键词: Internet; automated medical record system; biomarker; breast neoplasms; cancer information system; cancer registry /resource; cooperative study; female; genetic markers; histopathology; human tissue; information retrieval; neoplasm /cancer classification /staging; prognosis; tissue resource /registry

DESCRIPTION: (Applicant's Description) The St. Louis Breast Cancer Tissue Resource (STLBCTR) has been operational since the fall of 1993 and is one of four components (others are University of Miami, Miami, Florida; Fox Chase Cancer Center, Philadelphia, Pennsylvania; Kaiser Permanente Northwest Division, Portland, Oregon) of the Cooperative Breast Cancer Tissue Resource (CBCTR). The CBCTR provides clinical information (a minimum of five years follow-up) and archival tissue specimens from breast cancer cases collected from these four sections of the United States. 25 percent of CBCTR cases are from the STLBCTR. CBCTR materials are available to any qualified researcher and are primarily of interest for testing the prognostic value of breast cancer markers. CBCTR case information is organized in a searchable database that can be accessed via the internet. STLBCTR is currently comprised of collaborators from three medical centers (St. John's Mercy, St. Luke's, and Barnes/Jewish:Washington University) who provide, through their respective institutions, archival specimens and clinical information to be contributed to the CBCTR. The primary site for the STLBCTR is Washington University, where database development, management, and case distribution take place. We propose over the next five year period to continue the work of the St. Louis Project and participate in the combined efforts of the CBCTR group, namely we propose to carry out five Specific Aims which include: 1) For the next two years, we will concentrate on the further distribution of the archival breast cancer case materials to qualified researchers. 2) We will continue to maintain the STLBCTR databases. 3) We will continue efforts to inform the scientific community about the resource and solicit quality applications. 4) We will continue collaborative work with the Research Evaluation Panel (REP) of the CBCTR to: a) review applications for the use of archival tissues, b) provide tissues for approved applications, c) review and possibly revise the prioritization of uses for the remaining specimens, and 5) at the end of year two, we will assess the cases remaining in the Resource and develop an estimate of the cases that are expected to be requested for the next three years. If new case accrual is indicated by the CBCTR group the STLBCTR could potentially contribute 3,000 new cases.

描述：(申请人描述) 圣路易斯乳腺癌组织资源已投入使用 自1993年秋季以来，它是四个组成部分之一(其他是大学 佛罗里达州迈阿密迈阿密；费城福克斯·蔡斯癌症中心， 宾夕法尼亚州；Kaiser Permanente西北分区，俄勒冈州波特兰) 合作乳腺癌组织资源(CBCTR)。CBCTR提供了 临床资料(至少五年随访)和档案组织 从这四个部分收集的乳腺癌样本 美国。25%的CBCTR案例来自STLBCTR。CBCTR 任何有资格的研究人员都可以获得材料，主要是 有兴趣测试乳腺癌标记物的预后价值。CBCTR 案例信息组织在可访问的可搜索数据库中 通过互联网。STLBCTR目前由来自 三个医疗中心(圣约翰慈悲医院、圣卢克医院和 巴恩斯/犹太人：华盛顿大学)，他们通过各自的 提供的机构、档案标本和临床信息 到CBCTR。STLBCTR的主要地点是华盛顿大学， 在那里进行数据库开发、管理和案例分发。 我们建议在未来五年内继续圣彼得堡大学的工作。 路易斯项目，并参与CBCTR小组的共同努力， 也就是说，我们提出了五个具体目标，包括：1)针对 未来两年，我们将集中精力进一步分配 将乳腺癌病例资料存档给有资质的研究人员。2)我们会 继续维护STLBCTR数据库。3)我们将继续努力 向科学界通报资源和征集质量 申请。4)我们将继续与研究中心合作 《CBCTR》评估小组(代表)：a)审查使用申请 档案组织，b)为批准的申请提供组织，c)审查 并可能修改剩余标本的使用优先顺序， 和5)在第二年结束时，我们将评估剩余的病例 资源，并对预计将出现的案例进行评估 在接下来的三年里被要求。如果新案例的应计金额由 CBCTR小组STLBCTR可能会贡献3000个新病例。