ST LOUIS BREAST TISSUE REGISTRY

圣路易斯乳腺组织登记处

• 批准号: 6376046
• 负责人: BARBARA A ZEHNBAUER
• 金额: $ 13.16万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376046
• 关键词: Internet; automated medical record system; biomarker; breast neoplasms; cancer information system; cancer registry /resource; cooperative study; female; genetic markers; histopathology; human tissue; information retrieval; neoplasm /cancer classification /staging; prognosis; tissue resource /registry

DESCRIPTION: (Applicant's Description) The St. Louis Breast Cancer Tissue Resource (STLBCTR) has been operational since the fall of 1993 and is one of four components (others are University of Miami, Miami, Florida; Fox Chase Cancer Center, Philadelphia, Pennsylvania; Kaiser Permanente Northwest Division, Portland, Oregon) of the Cooperative Breast Cancer Tissue Resource (CBCTR). The CBCTR provides clinical information (a minimum of five years follow-up) and archival tissue specimens from breast cancer cases collected from these four sections of the United States. 25 percent of CBCTR cases are from the STLBCTR. CBCTR materials are available to any qualified researcher and are primarily of interest for testing the prognostic value of breast cancer markers. CBCTR case information is organized in a searchable database that can be accessed via the internet. STLBCTR is currently comprised of collaborators from three medical centers (St. John's Mercy, St. Luke's, and Barnes/Jewish:Washington University) who provide, through their respective institutions, archival specimens and clinical information to be contributed to the CBCTR. The primary site for the STLBCTR is Washington University, where database development, management, and case distribution take place. We propose over the next five year period to continue the work of the St. Louis Project and participate in the combined efforts of the CBCTR group, namely we propose to carry out five Specific Aims which include: 1) For the next two years, we will concentrate on the further distribution of the archival breast cancer case materials to qualified researchers. 2) We will continue to maintain the STLBCTR databases. 3) We will continue efforts to inform the scientific community about the resource and solicit quality applications. 4) We will continue collaborative work with the Research Evaluation Panel (REP) of the CBCTR to: a) review applications for the use of archival tissues, b) provide tissues for approved applications, c) review and possibly revise the prioritization of uses for the remaining specimens, and 5) at the end of year two, we will assess the cases remaining in the Resource and develop an estimate of the cases that are expected to be requested for the next three years. If new case accrual is indicated by the CBCTR group the STLBCTR could potentially contribute 3,000 new cases.

描述：（申请人的描述） 圣路易斯乳腺癌组织资源 (STLBCTR) 已投入运行 自 1993 年秋季以来，是四个组成部分之一（其他是大学 迈阿密，迈阿密，佛罗里达州；福克斯蔡斯癌症中心，费城， 宾夕法尼亚州；凯撒医疗机构西北分部（俄勒冈州波特兰） 合作乳腺癌组织资源 (CBCTR)。 CBCTR 提供 临床信息（至少五年随访）和档案组织 从这四个部分收集的乳腺癌病例标本 美国。 25% 的 CBCTR 案例来自 STLBCTR。 CBCTR 任何合格的研究人员都可以获得材料，并且主要是 对测试乳腺癌标志物的预后价值的兴趣。 CBCTR 案例信息组织在可搜索的数据库中，可以访问 通过互联网。 STLBCTR 目前由来自以下领域的合作者组成： 三个医疗中心（圣约翰慈善中心、圣路加医院和 Barnes/Jewish：华盛顿大学）通过各自的 提供机构、档案标本和临床信息 到 CBCTR。 STLBCTR 的主要站点是华盛顿大学， 数据库开发、管理和案例分发的地方。 我们建议在未来五年内继续圣保罗的工作。 圣路易斯项目和参与CBCTR小组的共同努力， 即我们建议实现五个具体目标，其中包括： 1） 未来两年，我们将集中精力进一步布局 向合格的研究人员提供存档乳腺癌病例材料。 2）我们会 继续维护 STLBCTR 数据库。 3）我们将继续努力 向科学界通报资源并征求质量意见 应用程序。 4）我们将继续与研究机构合作 CBCTR 评估小组 (REP) 的职责是： a) 审查使用申请 档案组织，b) 为批准的申请提供组织，c) 审查 并可能修改剩余样本的使用优先顺序， 5) 在第二年年底，我们将评估剩余的案件 资源并制定预期案例的估计 要求未来三年。 如果新案件应计情况由 CBCTR 小组 STLBCTR 可能会贡献 3,000 个新病例。