ST LOUIS BREAST TISSUE REGISTRY

圣路易斯乳腺组织登记处

• 批准号: 6172661
• 负责人: BARBARA A ZEHNBAUER
• 金额: $ 21.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6172661
• 关键词: Internet; automated medical record system; biomarker; breast neoplasms; cancer information system; cancer registry /resource; cooperative study; female; genetic markers; histopathology; human tissue; information retrieval; neoplasm /cancer classification /staging; prognosis; tissue resource /registry

DESCRIPTION: (Applicant's Description) The St. Louis Breast Cancer Tissue Resource (STLBCTR) has been operational since the fall of 1993 and is one of four components (others are University of Miami, Miami, Florida; Fox Chase Cancer Center, Philadelphia, Pennsylvania; Kaiser Permanente Northwest Division, Portland, Oregon) of the Cooperative Breast Cancer Tissue Resource (CBCTR). The CBCTR provides clinical information (a minimum of five years follow-up) and archival tissue specimens from breast cancer cases collected from these four sections of the United States. 25 percent of CBCTR cases are from the STLBCTR. CBCTR materials are available to any qualified researcher and are primarily of interest for testing the prognostic value of breast cancer markers. CBCTR case information is organized in a searchable database that can be accessed via the internet. STLBCTR is currently comprised of collaborators from three medical centers (St. John's Mercy, St. Luke's, and Barnes/Jewish:Washington University) who provide, through their respective institutions, archival specimens and clinical information to be contributed to the CBCTR. The primary site for the STLBCTR is Washington University, where database development, management, and case distribution take place. We propose over the next five year period to continue the work of the St. Louis Project and participate in the combined efforts of the CBCTR group, namely we propose to carry out five Specific Aims which include: 1) For the next two years, we will concentrate on the further distribution of the archival breast cancer case materials to qualified researchers. 2) We will continue to maintain the STLBCTR databases. 3) We will continue efforts to inform the scientific community about the resource and solicit quality applications. 4) We will continue collaborative work with the Research Evaluation Panel (REP) of the CBCTR to: a) review applications for the use of archival tissues, b) provide tissues for approved applications, c) review and possibly revise the prioritization of uses for the remaining specimens, and 5) at the end of year two, we will assess the cases remaining in the Resource and develop an estimate of the cases that are expected to be requested for the next three years. If new case accrual is indicated by the CBCTR group the STLBCTR could potentially contribute 3,000 new cases.

描述：（申请人的描述） 圣路易斯乳腺癌组织资源（STLBCTR）已开始运作， 自1993年秋季以来，是四个组成部分之一（其他是大学 of迈阿密，迈阿密，佛罗里达; Fox Chase癌症中心，费城， 宾夕法尼亚州;凯撒医疗机构西北分部，波特兰，俄勒冈州） 合作乳腺癌组织资源（CBCTR）。 CBCTR提供 临床信息（至少5年随访）和存档组织 从这四个部分收集的乳腺癌病例样本 美国的 25%的CBCTR病例来自STLBCTR。 CBCTR 材料是提供给任何合格的研究人员，主要是 对检测乳腺癌标志物的预后价值感兴趣。 CBCTR 案例信息被组织在可搜索的数据库中， 通过互联网 STLBCTR目前由来自 三个医疗中心（圣约翰慈善，圣卢克，和 巴恩斯/犹太人：华盛顿大学）谁提供，通过他们各自的 提供的机构、档案标本和临床信息 到CBCTR。 STLBCTR的主要站点是华盛顿大学， 在那里进行数据库开发、管理和病例分发。 我们建议在今后五年内继续开展圣三一学院的工作。 路易斯项目，并参与CBCTR集团的共同努力， 即我们建议实现五个具体目标，其中包括：1） 未来两年，我们将集中精力进一步分配 将乳腺癌病例资料提供给合格的研究人员。 2)我们将 继续维护STLBCTR数据库。 3)我们将继续努力， 向科学界通报资源情况并征求质量 应用. 4)我们将继续与研究 CBCTR的评估小组（REP）：a）审查使用 存档组织，B）为批准的申请提供组织，c）审查 并可能修订剩余标本的使用优先次序， （五）在第二年年底，我们会评估 提供资源并对预计将 要求在未来三年。 如果新病例累积由 CBCTR组STLBCTR可能会产生3,000例新病例。