GCRF-Crick African Network

GCRF-克里克非洲网络

• 批准号: MR/P028071/1
• 负责人: Jean Langhorne
• 金额: $ 807.35万
• 依托单位: The Francis Crick Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP028071%2F1
• 关键词: GCRF; Crick; African; Network

The extreme poverty faced by many people in Sub-Saharan Africa contributes to very high rates of infectious diseases, as well as to chronic diseases linked to these. Scientific research is needed to address these challenges, however, Africa also faces a shortage of knowledge, skills and research facilities, which compounds the problem. Our strategy to tackle this problem is to identify a group of African scientists who already have PhDs and show outstanding talent, and intensively develop their careers via targeted, high-level training and mentorship. The idea is to foster the next generation of leadership at key African research institutions that are well-positioned to advance science on the continent. The ultimate aim is to improve the health of the people of Africa and beyond.To achieve this, we will establish a new initiative, the 'Crick African Network' (CAN), which involves collaboration between the UK and Africa. The network's goal will be to help build capacity in African institutions to conduct research into infectious diseases that occur in poverty-stricken areas. The network will formally link the Francis Crick Institute (Crick) in the UK with a select group of African-based research organisations, namely: the Universities of Stellenbosch and Cape Town, South Africa, MRC Uganda Virus Research Institute (UVRI), the University of Ghana, and the West African Global Health Alliance (WAGHA) that includes MRC Gambia and University Cheikh Anta Diop, Sénégal.These partners will together provide an 'African Career Accelerator' programme that provides high-level training for talented African scientists. The programme will offer competitive fellowships that allow the scientists to spend time at Crick in the UK, receiving advanced training, with access to state-of-the-art Science Technology Platform (STP) facilities and expertise. It will then help them to re-establish their research portfolios back at their African institutions. We envisage ongoing mentorship of, and collaboration with, these future research leaders to encourage lasting, mutually beneficial, scientific partnerships. In conjunction with this, the network will host introductory workshops in key African locations, to inform and inspire infectious diseases researchers from those regions. It will also hold annual scientific meetings for the four-year duration of the programme to encourage exchange of scientific learning, grow collaborations and engage with relevant health sector stakeholders.By intensively developing this select group of up-and-coming researchers, connecting them internationally, supporting them with world-class expertise and positioning them in strong African institutions that can serve as hubs of scientific excellence within the continent, we hope they will become a powerful cadre of internationally connected research professionals with the expertise and experience needed to tackle Africa's infectious disease challenges. The UK-African network formed will also be well positioned to respond, through biomedical research, to pressing poverty-related health needs affecting the welfare and economic development of Africa.

撒哈拉以南非洲许多人面临的极端贫困导致了传染病的高发病率，以及与此相关的慢性疾病。需要科学研究来应对这些挑战，然而，非洲也面临着知识、技能和研究设施的短缺，这加剧了问题。我们解决这一问题的战略是找到一批已经拥有博士学位并表现出杰出才华的非洲科学家，并通过有针对性的高水平培训和指导来密集发展他们的职业生涯。这一想法是为了在非洲关键研究机构培养下一代领导层，这些机构处于有利地位，可以推动非洲大陆的科学发展。最终目标是改善非洲和非洲以外地区人民的健康。为了实现这一目标，我们将建立一个新的倡议--克里克非洲网络(CAN)，其中包括英国和非洲之间的合作。该网络的目标将是帮助非洲机构建设能力，对贫困地区发生的传染病进行研究。该网络将正式将英国的弗朗西斯·克里克研究所(Crick)与一些非洲研究机构联系起来，这些研究机构是：南非斯泰伦博斯大学和开普敦大学、乌干达MRC病毒研究所(UVRI)、加纳大学和西非全球卫生联盟(Wagha)，该联盟包括MRC冈比亚和Cheikh Anta Diop大学，Sénégala大学。这些合作伙伴将共同提供“非洲职业加速器”计划，为有才华的非洲科学家提供高水平的培训。该计划将提供竞争性的奖学金，允许科学家们在英国克里克度过一段时间，接受高级培训，并获得最先进的科学技术平台(STP)设施和专业知识。然后，它将帮助他们重新建立他们在非洲机构的研究组合。我们设想对这些未来的研究领导者进行持续的指导和合作，以鼓励持久的、互惠互利的科学伙伴关系。同时，该网络将在非洲主要地点举办介绍性讲习班，以向这些地区的传染病研究人员提供信息并激励他们。它还将在该方案为期四年的时间里举行年度科学会议，以鼓励科学学习的交流，加强合作，并与相关卫生部门的利益攸关方接触。通过密集培养这群崭露头角的研究人员，在国际上将他们联系起来，将他们与国际上的专业知识联系起来，为他们提供世界级的专业知识支持，并将他们安置在强大的非洲机构中，这些机构可以作为非洲大陆内卓越的科学中心，我们希望他们将成为一支强大的研究专业队伍，拥有应对非洲传染病挑战所需的专业知识和经验。形成的英国-非洲网络也将处于有利地位，通过生物医学研究，应对影响非洲福利和经济发展的与贫困相关的紧迫健康需求。

项目成果

Development of Cooperative Primer-Based Real-Time PCR Assays for the Detection of Plasmodium malariae and Plasmodium ovale.

• DOI: 10.1016/j.jmoldx.2021.07.022
• 发表时间: 2021-10
• 期刊: The Journal of molecular diagnostics : JMD
• 作者: Ansah F;Suurbaar J;Darko D;Anabire NG;Blankson SO;Domson BKS;Soulama A;Kpasra P;Chirawurah JD;Amenga-Etego L;Kanyong P;Awandare GA;Aniweh Y
• 通讯作者: Aniweh Y

10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity.

• DOI: 10.12688/wellcomeopenres.16562.3
• 发表时间: 2021
• 期刊: Wellcome open research
• 作者: Addy JWG;Bediako Y;Ndungu FM;Valetta JJ;Reid AJ;Mwacharo J;Ngoi JM;Wambua J;Otieno E;Musyoki J;Said K;Berriman M;Marsh K;Bejon P;Recker M;Langhorne J
• 通讯作者: Langhorne J

Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana.

加纳卵形疟原虫和恶性疟原虫野外分离株对参考药物和主要候选抗疟药物的敏感性比较。

• DOI: 10.1128/spectrum.04916-22
• 发表时间: 2023-06-15
• 期刊: Microbiology spectrum
• 影响因子: 3.7

Synthesis and initial testing of novel antimalarial and antitubercular isonicotinohydrazides

• DOI: 10.1016/j.rechem.2022.100287
• 发表时间: 2022-01-26
• 期刊: RESULTS IN CHEMISTRY
• 影响因子: 2.3
• 作者: Amewu, Richard K.;Ade, Crystal F.;Yeboah-Manu, Dorothy
• 通讯作者: Yeboah-Manu, Dorothy

Ultrasensitive electrochemical genosensors for species-specific diagnosis of malaria.

• DOI: 10.1016/j.electacta.2022.140988
• 发表时间: 2022-10-10
• 期刊: ELECTROCHIMICA ACTA
• 影响因子: 6.6
• 作者: Ansah, Felix;Krampa, Francis;Donkor, Jacob K.;Owusu-Appiah, Caleb;Ashitei, Sarah;Kornu, Victor E.;Danku, Reinhard K.;Chirawurah, Jersley D.;Awandare, Gordon A.;Aniweh, Yaw;Kanyong, Prosper
• 通讯作者: Kanyong, Prosper