Stratified interventions in ARDS (EMINENT)

ARDS 的分层干预措施 (EMINENT)

• 批准号: MR/P502091/1
• 负责人: Charlotte Summers
• 金额: $ 39.08万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP502091%2F1
• 关键词: Stratified; interventions; ARDS; EMINENT

There is an urgent and unmet need to define disease pathogenesis in acute respiratory distress syndrome (ARDS), and to develop rapid diagnostics to aid patient stratification and support targeted intervention. This is a programmatic approach to define disease pathogenesis in ARDS, and to develop rapid diagnostics to aid patient stratification and support targeted intervention.

目前迫切需要确定急性呼吸窘迫综合征 (ARDS) 的发病机制，并开发快速诊断方法来帮助患者分层并支持有针对性的干预。这是一种确定 ARDS 疾病发病机制的程序化方法，并开发快速诊断方法以帮助患者分层并支持有针对性的干预。

项目成果

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

• DOI: 10.1172/jci90848
• 发表时间: 2017-09-01
• 期刊: The Journal of clinical investigation
• 作者: Sadiku P;Willson JA;Dickinson RS;Murphy F;Harris AJ;Lewis A;Sammut D;Mirchandani AS;Ryan E;Watts ER;Thompson AAR;Marriott HM;Dockrell DH;Taylor CT;Schneider M;Maxwell PH;Chilvers ER;Mazzone M;Moral V;Pugh CW;Ratcliffe PJ;Schofield CJ;Ghesquiere B;Carmeliet P;Whyte MK;Walmsley SR
• 通讯作者: Walmsley SR

A Randomized Trial of Otilimab in Severe COVID-19 Pneumonia (OSCAR)

• DOI: 10.1101/2021.04.14.21255475
• 发表时间: 2021-04
• 期刊: Drugs in Context
• 作者: J. Patel;A. Beishuizen;Xavier Bocca Ruiz;H. Boughanmi;A. Cahn;G. Criner;K. Davy;J. de-Miguel-Diez;S. Fernandes;B. François;Anubha Gupta;K. Hanrott;T. Hatlen;D. Inman;J. Isaacs;Emily Jarvis;N. Kostina;J. Lacherade;P. Martínez-Ayala;C. Mcevoy;R. Muñoz-Bermúdez;J. Neisen;G. Plantefeve;L. Schifano;L. Schwab;Zainab Shahid;M. Shirano;Julia E Smith;E. Sprinz;C. Summers;N. Terzi;M. Tidswell;R. Williamson;D. Wyncoll;M. Layton

Reduced circulating BMP9 and pBMP10 in hospitalized COVID-19 patients.

• DOI: 10.1002/pul2.12192
• 发表时间: 2023-01
• 期刊: PULMONARY CIRCULATION
• 影响因子: 2.6
• 作者: Dunmore, Benjamin J.;Upton, Paul D.;Auckland, Kate;Samanta, Romit J.;Lyons, Paul A.;Smith, Kenneth G. C.;Graf, Stefan W.;Summers, Charlotte;Morrell, Nicholas
• 通讯作者: Morrell, Nicholas

Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research.

• DOI: 10.1183/16000617.0317-2020
• 发表时间: 2021-03-31
• 期刊: European respiratory review : an official journal of the European Respiratory Society
• 作者: Bos LDJ;Artigas A;Constantin JM;Hagens LA;Heijnen N;Laffey JG;Meyer N;Papazian L;Pisani L;Schultz MJ;Shankar-Hari M;Smit MR;Summers C;Ware LB;Scala R;Calfee CS
• 通讯作者: Calfee CS

Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.

LUKPQ的鉴定，这是金黄色葡萄球菌的新型，均等的白细胞素。

• DOI: 10.1038/srep40660
• 发表时间: 2017-01-20
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Koop G;Vrieling M;Storisteanu DM;Lok LS;Monie T;van Wigcheren G;Raisen C;Ba X;Gleadall N;Hadjirin N;Timmerman AJ;Wagenaar JA;Klunder HM;Fitzgerald JR;Zadoks R;Paterson GK;Torres C;Waller AS;Loeffler A;Loncaric I;Hoet AE;Bergström K;De Martino L;Pomba C;de Lencastre H;Ben Slama K;Gharsa H;Richardson EJ;Chilvers ER;de Haas C;van Kessel K;van Strijp JA;Harrison EM;Holmes MA
• 通讯作者: Holmes MA