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MOLECULAR CLONING OF CARNITINE/ACYLCARNITINE TRANSLOCASE

MOLECULAR CLONING OF CARNITINE/ACYLCARNITINE TRANSLOCASE
肉碱/酰基肉碱转位酶的分子克隆
批准号：
2883163
负责人：
TOD GULICK
金额：
$8.55万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-03-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/2883163
关键词：
carnitine complementary DNA fibroblasts gene mutation human genetic material tag mitochondria mitochondrial DNA molecular cloning nucleic acid sequence protein structure function structural genes tissue /cell culture transport proteins

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中文摘要
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英文摘要
DESCRIPTION (Adapted from applicant's description): The objective of this project is the cloning of the gene encoding mitochondrial carnitine/acylcarnitine translocase. The new set of Specific Aims include: 1) cloning and sequencing of the human CAC, cDNA and structural gene, 2) sequencing of CAC deficiency mutant genes, 3) examination of the expression of the mutant genes in mutant fibroblast cell lines, 4) creation of mutants in a yeast gene, yOR100c, that they believe to be yeast CAC and assessment of its genetic function, and 5) assaying CAC activity in mammalian cells in which mutant and wild-type CAC has been introduced.
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An interdisciplinary approach to elucidate mechanisms of muscle lipotoxicity
Mitochondrial Nucleotide Carriers of NRTI Metabolites
  • 批准号：
    6804111
  • 项目类别：
  • 资助金额：
    $38.56万
  • 财政年份：
    2003
  • 负责人：
    TOD GULICK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Mitochondrial Nucleotide Carriers of NRTI Metabolites
  • 批准号：
    6936621
  • 项目类别：
  • 资助金额：
    $38.56万
  • 财政年份：
    2003
  • 负责人：
    TOD GULICK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Mitochondrial Nucleotide Carriers of NRTI Metabolites
  • 批准号：
    7115805
  • 项目类别：
  • 资助金额：
    $37.48万
  • 财政年份：
    2003
  • 负责人：
    TOD GULICK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
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