Development of antibodies to Il-13 receptor and their preclinical testing in a sheep model for human allergic asthma
Development of antibodies to Il-13 receptor and their preclinical testing in a sheep model for human allergic asthma
IL-13受体抗体的开发及其在人类过敏性哮喘绵羊模型中的临床前测试
批准号：
nhmrc : 310603
负责人：
Dr Robert Bischof
金额：
$29.03万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Early Career Fellowships
财政年份：
2004
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2004-01-01 至 2008-12-31
中文摘要
翻译
世界范围内哮喘的患病率和严重程度的增加突出了对治疗这种疾病的新方法的需求。这一提议将产生抗体，可用于特异性阻断一种已知的调节哮喘疾病许多标志性特征的关键分子的作用。在已建立的绵羊哮喘模型中对这些抗体进行临床前评估，将允许它们作为哮喘的特异性治疗方法进行评估。
英文摘要
The increasing prevalence and severity of asthma worldwide highlights the need for novel approaches to treat this disease. This proposal will generate antibodies that can be used to specifically block the action of a key molecule known to regulate many of the hallmark features of asthmatic disease. Preclinical evaluation of these antibodies in an established sheep model of human asthma will allow their assessment as a specific therapy for asthma.
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